DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	XP_006238118.1	Gene:	Tbc1d2 / 313234	RGDID:	1306860	Length:	924	Species:	Rattus norvegicus

Alignment Length:	358	Identity:	109/358 - (30%)
Similarity:	175/358 - (48%)	Gaps:	40/358 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DATASSKFSDVDEYGFKRGDHFDYNNYSKFMDGYLKTLTR---------RRMKWEAILQQNTD-- 55
            |:...|..|:.|:|||.....::..:        ||.|.:         ..:..||:.:...|
  Rat   546 DSVGLSPVSEYDDYGFLTVPDYEVED--------LKLLAKIQALEVRSHHLLALEAVERPLRDRW 602

  Fly    56 --LTQV--DAKLKRYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLL-RTEPFDKEISDSIS 115
              ||::  .|:||:.:|.|:|..:||.||..:.........|...::.|| |....:...:..|.
  Rat   603 ATLTELMPSAELKQLLRAGVPREHRPRVWRWLVHRRVQHLHSSGCYQELLARGRACEHPAARQIE 667

  Fly   116 IDLPRTFPDNIHFDMK----KQRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLL 176
            :||.||||.|.||...    ..:|..:|:|::..|..:|||||||.:|.:.|:|.:|||.:||.|
  Rat   668 LDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCL 732

  Fly   177 KHIVENIVP-QYHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVL 240
            ..|||.|:| :|:|..:.....|..|.::|:..::|.:..|:....:...:|...||:.|||:.|
  Rat   733 VAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQRHVDLSLITFNWFLVIFADSL 797

  Fly   241 PVETVLRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDD---IAALANLFRDTMIQDNIVT--- 299
            ..:.:||:||....||.|:|||.||.:|..::.|||...|   |......|..|:.....:|
  Rat   798 ISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILRLQDSLEIYQYLRFFTKTICDSRKLTSIA 862

  Fly   300 --DCHGF-VEAMFSLR-LKRSELES-LRKVAVL 327
              |.:.| ::.:..|| ..|..||: ||::.:|
  Rat   863 FNDMNPFPMKQLRQLRAAHRERLEAELRELELL 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	74/214 (35%)
Tbc1d2	XP_006238118.1	PH_TBC1D2A	44..145	CDD:269966
		PH	44..137	CDD:278594
		TBC	621..833	CDD:214540	73/211 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100958
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720