DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and TBC1D12

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_056003.1	Gene:	TBC1D12 / 23232	HGNCID:	29082	Length:	775	Species:	Homo sapiens

Alignment Length:	313	Identity:	69/313 - (22%)
Similarity:	132/313 - (42%)	Gaps:	54/313 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KTLTRRRMK-----------WEAILQQNTDLTQVDAKLKRYIRKGIPGPYRPDVWMKISGAAAAQ 90
            |.:.:.|.|           |...:..|.::.:...:::....:|:|...|..||....|...
Human   440 KRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNEL-- 502

  Fly    91 RRSPDLFRNLL-----RTEPF---------------DKEIS-DSISIDLPRTFPDNIHFDMK--- 131
            ..:|:|:...|     |.:.|               |:|.| :.|.:|:.|||| :::...|
Human   503 NITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFP-SLYIFQKGGP 566

  Fly   132 -KQRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIVE---NIVPQYHSHNM 192
             ...|::||.||..:..||||.||:::||. :||:..:|..:|....:::.   .:......|:|
Human   567 YHDVLHSILGAYTCYRPDVGYVQGMSFIAA-VLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM 630

  Fly   193 ANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGY 257
              :|:..|.|.......:..:..|..:..|...:....|...::::.||::...|:||....:|.
Human   631 --MLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGE 693

  Fly   258 KIVFRAALTMFVTHKNAILGCDDIAALANLFRDTMIQDNIVTDCHGFVEAMFS 310
            :.:||..|.:...:::.:|..|.|.....|   |.:.::|.:      |.:||
Human   694 EFLFRTGLGILRLYEDILLQMDFIHIAQFL---TKLPEDITS------EKLFS 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	55/236 (23%)
TBC1D12	NP_056003.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..312
		TBC	481..712	CDD:214540	55/236 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810