DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and TBC1D2B

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001374071.1	Gene:	TBC1D2B / 23102	HGNCID:	29183	Length:	974	Species:	Homo sapiens

Alignment Length:	359	Identity:	99/359 - (27%)
Similarity:	165/359 - (45%)	Gaps:	55/359 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDVDEYGFKR--GDHFDYNNYSKFMDGYLKT--LTRRR-----MKWEAILQQNTDLTQV-DAKLK 64
            |:.|.|||:.  .|..:....:|.....|||  ||..:     :|||.......:...: ..:||
Human   592 SEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELK 656

  Fly    65 RYIRKGIPGPYRPDVW--------MKISGAAAAQRRSPDLFRNLLRTEPFDKE--ISDSISIDLP 119
            ..||.|||..:|..||        .|..     ....|..|:.||: :..:|:  .|..|.:||.
Human   657 NLIRAGIPHEHRSKVWKWCVDRHTRKFK-----DNTEPGHFQTLLQ-KALEKQNPASKQIELDLL 715

  Fly   120 RTFPDNIHFDMKK----QRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIV 180
            ||.|:|.|:....    |:|.|:|:|::..|.|:|||||||.:..:.|:..:.|: :||.|..||
Human   716 RTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQED-AFWCLVTIV 779

  Fly   181 ENIVPQ-YHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVET 244
            |..:|: |::..:.....|..|||:|:..::|.::.|.:...:.|.:|...||:.:|.:.:..:.
Human   780 EVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDI 844

  Fly   245 VLRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDDIAALANLFRDTMIQDNIVTDCHGFVEAMF 309
            :.:|||....||.|::||.||.:|...:..||...|   ..::|:........:.|....:...|
Human   845 LFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD---SMSIFKYLRYFTRTILDARKLISISF 906

  Fly   310 --------------------SLRLKRSELESLRK 323
                                .:||:.:|||::|:
Human   907 GDLNPFPLRQIRNRRAYHLEKVRLELTELEAIRE 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	70/223 (31%)
TBC1D2B	NP_001374071.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		PH_TBC1D2A	36..144	CDD:269966
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..348
		Smc	<338..552	CDD:224117
		RabGAP-TBC	665..876	CDD:366170	65/217 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100958
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720