DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and Tbc1d12

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_666064.3	Gene:	Tbc1d12 / 209478	MGIID:	2384803	Length:	698	Species:	Mus musculus

Alignment Length:	313	Identity:	69/313 - (22%)
Similarity:	132/313 - (42%)	Gaps:	54/313 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KTLTRRRMK-----------WEAILQQNTDLTQVDAKLKRYIRKGIPGPYRPDVWMKISGAAAAQ 90
            |.:.:.|.|           |...:..|.::.:...:::....:|:|...|..||....|...
Mouse   363 KRIMKERFKQEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNEL-- 425

  Fly    91 RRSPDLFRNLL-----RTEPF---------------DKEIS-DSISIDLPRTFPDNIHFDMK--- 131
            ..:|:|:...|     |.:.|               |:|.| :.|.:|:.|||| :::...|
Mouse   426 NITPELYEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFP-SLYIFQKGGP 489

  Fly   132 -KQRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIVE---NIVPQYHSHNM 192
             ...|::||.||..:..||||.||:::||. :||:..:|..:|....:::.   .:......|:|
Mouse   490 YHDVLHSILGAYTCYRPDVGYVQGMSFIAA-VLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM 553

  Fly   193 ANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGY 257
              :|:..|.|.......:..:..|..:..|...:....|...::::.||::...|:||....:|.
Mouse   554 --MLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGE 616

  Fly   258 KIVFRAALTMFVTHKNAILGCDDIAALANLFRDTMIQDNIVTDCHGFVEAMFS 310
            :.:||..|.:...:::.:|..|.|.....|   |.:.::|.:      |.:||
Mouse   617 EFLFRTGLGILRLYEDILLQMDFIHIAQFL---TKLPEDITS------EKLFS 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	55/236 (23%)
Tbc1d12	NP_666064.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..236
		COG5210	304..639	CDD:227535	61/281 (22%)
		RabGAP-TBC	468..635	CDD:278964	41/170 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810