DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and tbc-19

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_510336.3	Gene:	tbc-19 / 181511	WormBaseID:	WBGene00007849	Length:	1333	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	94/347 - (27%)
Similarity:	154/347 - (44%)	Gaps:	43/347 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VDEYGFK-------RGDHFDYNNYSKFMDGYLKTLTRRRMKWEAILQQNTDLTQVDAKLKRYIRK 69
            ||.:||:       ...|:.....:.|.....|:.:..:..|:..|::| |...:..:.|...||
Worm   387 VDSFGFRISFKEEPNALHYMATKLNHFYANRSKSASEHKYNWKRFLEEN-DFIDLTPETKIMCRK 450

  Fly    70 GIPGPYRPDVWMKISGAAAAQRRSPDL--------FRNLLRTE--PFDKEISD----SISIDLPR 120
            |||...|..|| ||    ...::..||        :|||...:  ..:|..||    .|::||.|
Worm   451 GIPNSLRATVW-KI----LINQQVEDLKNVYGKYYYRNLCNIQGGEDEKTYSDVHQKQINLDLLR 510

  Fly   121 TFPDNIHFDMKKQR----LYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIVE 181
            |.|:|:||.....:    |..:|.|:..||..:|||||:|::|...|:....|: :||.|..:.|
Worm   511 TMPNNVHFMSANSKGVTQLLQVLHAFCLHNSQIGYCQGMNFLAATALLFVGPED-AFWFLIAVTE 574

  Fly   182 NIVPQ-YHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVETV 245
            ....: |...|:.....|..|.:.|:..:.|.:.:|:.:|.:........|||.:|.:.:|..|:
Worm   575 RYFDKTYFDSNLTGAQADQEVLKGLLEVQHPKIMKHLKSLDIDVASFTLNWFISLFFDAVPFNTL 639

  Fly   246 LRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDDIAALANLFRDTMIQDNIVTDCHGFVEAMF- 309
            ||||||...||.|::||.|:.:...|:..|:...|   ...:.|.:.....:..|....|...|
Worm   640 LRIWDCFLLEGPKVLFRFAIVLIGKHEEEIISRGD---AIGIMRVSKAATKLAFDEEAIVNMAFR 701

  Fly   310 ------SLRLKRSELESLRKVA 325
                  .:.||..:|:.:..:|
Worm   702 IPNLPTRIELKNMQLQYVNLLA 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	72/227 (32%)
tbc-19	NP_510336.3	PH-like	13..112	CDD:302622
		PH	16..110	CDD:278594
		TBC	448..670	CDD:214540	72/227 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820