DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and tbc-8

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001255072.1	Gene:	tbc-8 / 176454	WormBaseID:	WBGene00008018	Length:	913	Species:	Caenorhabditis elegans

Alignment Length:	350	Identity:	81/350 - (23%)
Similarity:	134/350 - (38%)	Gaps:	82/350 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VDEYGFK--RGDHFDYNN-------YSKFMDGYLKTLTRRRMKW-------------EAILQQNT 54
            |||..:|  |.:..:.|.       |.:.::| :.|...|||.|             |:.|:|.|
Worm   565 VDEKFWKQARAEPTEENEKEFLKRVYWRGIEG-INTKEVRRMAWPYLLGLFEWNESPESRLEQFT 628

  Fly    55 DLTQVDAK----LKRYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLLRTEP-----FDKEI 110
            .....|.:    |:..:|:.....:|.....|  .|:..:..|.|:|.:  ..||     :|:|
Worm   629 SQYWQDIEEWRVLEAEVRRRDEEAFRAARARK--AASPVREESCDVFED--PNEPTCSQHYDRE- 688

  Fly   111 SDSISIDLPRTFPDNIH---------------FDMKK--QRLYNILIAYAHHNRDVGYCQGLNYI 158
                  :|...|..|:|               |..|.  :.|..::..|...|.:.||.||:..:
Worm   689 ------NLITLFRANLHRIDKDVERCDRNLMFFSNKDNLESLRRVMYTYVRRNLEEGYTQGMCDL 747

  Fly   159 AGLLLIVTDDEE---KSFWLLKHIVENIVPQYHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNL 220
            ...||:..:||.   :.|.||........||  ...|:..|.:|....::|..:|.|:...:|..
Worm   748 LAPLLVTFEDEALTLECFSLLMLRQRGKFPQ--RPGMSKCLLNLRSLIQVVDPQIYALISDIDYA 810

  Fly   221 -GLPYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDDIAAL 284
             .|.:   |.:||:..|...|..|...::|:.::         ||..:.:|...||.  ..:|.:
Worm   811 QALSF---AFRWFLLDFKRELSYECTYKVWEVIW---------AAQRLRITDDFAIF--FGLATI 861

  Fly   285 ANLFRDTMIQDNI-VTDCHGFVEAM 308
            .| :.|.:|.:|. .||...|...|
Worm   862 TN-YHDVLITNNFDYTDMIKFFNEM 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	52/234 (22%)
tbc-8	NP_001255072.1	RUN	177..237	CDD:214736
		PH_RUTBC	299..467	CDD:275431
		TBC	670..869	CDD:214540	51/224 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910