DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5916 and tbc1d2b

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	XP_002666912.2	Gene:	tbc1d2b / 100330777	ZFINID:	ZDB-GENE-100922-148	Length:	946	Species:	Danio rerio

Alignment Length:	357	Identity:	100/357 - (28%)
Similarity:	166/357 - (46%)	Gaps:	51/357 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDVDEYGFK-----RGDHFDYNNYSKFMDGYLKTL------TRRRMKWEAIL--QQNTDLTQVDA 61
            |:.|.||||     ..:........:.:|  ||:|      |..|:||:..|  ..|.::.: ..
Zfish   575 SEYDIYGFKTVPEEEDEEEKLEAKKRALD--LKSLSLTDQETSVRVKWDNYLAITMNREMVR-SP 636

  Fly    62 KLKRYIRKGIPGPYRPDVWMKISGAAAAQRRS---PDLFRNLL-----RTEPFDKEISDSISIDL 118
            .||..:|.|:|..:|..||.........:.|.   .|.:.|||     :..|..|:    |.:||
Zfish   637 DLKALMRGGVPHIHRSKVWSWCVSFHVKKMRDCQPKDYYHNLLCMANDKPNPACKQ----IELDL 697

  Fly   119 PRTFPDNIHFDMKK----QRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHI 179
            .||.|:|.|:....    |:|.|:|:|::..|.|:|||||||.:|.:.|:..|.|: :||.|..|
Zfish   698 LRTLPNNKHYSSPDSDGIQKLRNVLLAFSWRNPDIGYCQGLNRLAAIALLYLDQED-AFWCLVAI 761

  Fly   180 VENIVP-QYHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVE 243
            ||..:| .|::..:.....|..||::|:..::|.::.|.::..:.:.:|...||:.:|.:.:..:
Zfish   762 VEVFMPHDYYTKTLLGSQVDQRVFKDLMYEKLPRLHAHFEHYKVDFSLITFNWFLVVFVDSVVSD 826

  Fly   244 TVLRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDDIAALANLFR--DTMIQDNIVTDCHGFVE 306
            .:.:|||....||.||:||.||.:|...:...|...|...:....|  ...|.|........||:
Zfish   827 ILFKIWDSFLYEGPKIIFRFALALFKYKEEEFLKLQDPMTIFKYLRYFTRTILDARKLMAMAFVD 891

  Fly   307 A---------------MFSLRLKRSELESLRK 323
            .               :..:||:.:|||::|:
Zfish   892 MNPFPLRQIQNRRTFHLEKVRLELTELEAIRQ 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	69/221 (31%)
tbc1d2b	XP_002666912.2	PH_TBC1D2A	37..137	CDD:269966
		PH	37..129	CDD:278594
		CtIP_N	307..415	CDD:287457
		TPR_MLP1_2	313..434	CDD:285204
		USP8_interact	317..>359	CDD:286082
		TBC	643..859	CDD:214540	69/220 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100958
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720