Protein Alignment Sb and TMPRSS13

DIOPT Version :10

• Sequence 1: NP_476709.1
• Gene: Sb / 41958
• FlyBaseID: FBgn0003319
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001070731.1
• Gene: TMPRSS13 / 84000
• HGNCID: 29808
• Length: 567
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 170/634 - (26%)
• Similarity: 250/634 - (39%)
• Gaps: 192/634 - (30%)

  Fly   258 DLHGSAS---HPSSSSSSSSSSNPNSIWHTSTQQQQQQQHQQNQQNHWQMTTEPSFITKPRPTGW 319
            |.||:||   .||:.:|.:.:|                                       |.|
Human     4 DSHGNASPARTPSAGASPAQAS---------------------------------------PAG- 28

  Fly   320 TKPGIVNLPMPARPSKPSKPTKKPIVYDRTPP----PPPSVPPSTSTSTTSTSLIWPAQTHPPQP 380
            |.||..: |..|.|::.|..        .|||    |..:.|..|.....|.....|||..|.|.
Human    29 TPPGRAS-PAQASPAQASPA--------GTPPGRASPAQASPAGTPPGRASPGRASPAQASPAQA 84

  Fly   381 HRPTRPQLSPG-TSLAASSSSHWPSSTTSTTSSTTSTTTTTTTTRRTTTPTTTTRRTTTNKPTRP 444
             .|.|  .||. .||:.|||..   |:::.::|.|::.|.....|.|.......|    :.|.|
Human    85 -SPAR--ASPALASLSRSSSGR---SSSARSASVTTSPTRVYLVRATPVGAVPIR----SSPAR- 138

  Fly   445 YQRPTTATSSSSTSTTSSKTPTTTR------PISSSS-----------------SSSSGIVTSSQ 486
             ..|.|..:..|..|:..|  .|.|      |:....                 ...:||....|
Human   139 -SAPATRATRESPGTSLPK--FTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQ 200

  Fly   487 RPTQPTHRT--------------------------------------PVLATS------------ 501
            |.:.|.|..                                      |:.:::
Human   201 RESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQ 265

  Fly   502 -GIE----TNEISDSSIPDA-GALGHVKTI--SAARSECGVPT------------LARPETRIVG 546
             |.|    |.|::.....:: ..|.:..||  |..||||  |:            |.....||||
Human   266 LGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSEC--PSQRYISLQCSHCGLRAMTGRIVG 328

  Fly   547 GKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQIRIRVG--EYDF 609
            |..|:..:||||||:.      |.:||.|||.||:..|:.||.||   ..:::.::..|  .|..
Human   329 GALASDSKWPWQVSLH------FGTTHICGGTLIDAQWVLTAAHC---FFVTREKVLEGWKVYAG 384

  Fly   610 SHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLP---ETDSLLIGM 671
            :....|||. ...:|:.:::..|:....:||:||::|.:||..:.|:.|.|||   :|.||
Human   385 TSNLHQLPE-AASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSL---- 444

  Fly   672 NAT--VTGWGRLSEGGTLPS-VLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDS 733
            |.|  :||:|:..|.....| .|:||.|.::....|....:   ...::....:|||...||:||
Human   445 NETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLV---YDSYLTPRMMCAGDLRGGRDS 506

  Fly   734 CQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
            |||||||||..: |:.|::|||:.|||.||.:.|.|||.|::::..|||
Human   507 CQGDSGGPLVCE-QNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_476709.1	Tryp_SPc	544..785	CDD:238113	92/247 (37%)
TMPRSS13	NP_001070731.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		42/165 (25%)
		PHA03378	<9..148	CDD:223065	47/199 (24%)
		13 X 5 AA repeats of A-S-P-A-[GLQR]	9..93		31/135 (23%)
		4 X 5 AA repeats of T-P-P-G-R	14..68		19/102 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	131..157		8/33 (24%)
		SRCR_2	231..321	CDD:464747	15/91 (16%)
		Tryp_SPc	325..554	CDD:214473	91/246 (37%)