Protein Alignment Sb and TMPRSS2

DIOPT Version :10

• Sequence 1: NP_476709.1
• Gene: Sb / 41958
• FlyBaseID: FBgn0003319
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001128571.1
• Gene: TMPRSS2 / 7113
• HGNCID: 11876
• Length: 529
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 139/522 - (26%)
• Similarity: 202/522 - (38%)
• Gaps: 118/522 - (22%)

  Fly   330 PARPSKPSKPTKKPIVYDRTPPPPPSVPPSTSTSTTSTSLIWPAQTHPPQPHRPTRPQLSPGTSL 394
            |..| .|::||..|.||                           :.||.|.:....||.:|....
Human    59 PENP-YPAQPTVVPTVY---------------------------EVHPAQYYPSPVPQYAPRVLT 95

  Fly   395 AASSSSHWPSSTTSTTSSTTSTTTTTTTTRRTTTPTTTTRRTTTNKPTRP---YQRPTTATSSSS 456
            .||      :....|...:.|.|..|:.|::....|.|............   ::...:..|:|.
Human    96 QAS------NPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSG 154

  Fly   457 TSTTSSKTPTTTRPISSSSSSSSGI-----------------------VTSSQRPT--------- 489
            ....||.|      ..:.|:...|:                       |.||||.:
Human   155 IECDSSGT------CINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDW 213

  Fly   490 QPTHRTPVLATSGIETNEISDSSI-PDAGALGHVKTISAARS----------------------- 530
            ...:........|.:.|..|...| .|:|:...:|..::|.:
Human   214 NENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRC 278

  Fly   531 -ECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDD 594
             .|||...:..::|||||:||..|.||||||:.      ..:.|.|||::|...||.||.|||:.
Human   279 IACGVNLNSSRQSRIVGGESALPGAWPWQVSLH------VQNVHVCGGSIITPEWIVTAAHCVEK 337

  Fly   595 LLISQIRIRVGEYDFSHV-QEQLPYIERG--VAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHV 656
            .|.:......    |:.: ::...:...|  |.|.:.||.|...|...|:||:||::||.|...|
Human   338 PLNNPWHWTA----FAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLV 398

  Fly   657 SPICLPETDSLLIGMN-ATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDI 720
            .|:|||....:|.... ..::|||...|.|....||....|.::....|.|.::   ....|...
Human   399 KPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYV---YDNLITPA 460

  Fly   721 FLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEH 785
            .:|||:..|..||||||||||| ..|::..::|.|..|||.|||:|..|||...:..||.||...
Human   461 MICAGFLQGNVDSCQGDSGGPL-VTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQ 524

  Fly   786 VR 787
            :|
Human   525 MR 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_476709.1	Tryp_SPc	544..785	CDD:238113	91/244 (37%)
TMPRSS2	NP_001128571.1	LDLa	150..185	CDD:238060	7/40 (18%)
		SRCR_2	190..283	CDD:464747	14/92 (15%)
		Tryp_SPc	293..524	CDD:238113	91/244 (37%)