DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	279	Identity:	109/279 - (39%)
Similarity:	143/279 - (51%)	Gaps:	35/279 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 ALGHVKTISAARSECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINE 582
            |.|||.|:..  :.||  ......:|||||..:...:||||.|::      |...|.|||::|..
Human   195 ASGHVVTLQC--TACG--HRRGYSSRIVGGNMSLLSQWPWQASLQ------FQGYHLCGGSVITP 249

  Fly   583 NWIATAGHCVDDLLISQI-RIRVGEYDF------SHVQEQLPYIERGVAKKVVHPKYSFLTYEYD 640
            .||.||.|||.||.:.:. .|:||....      ||:.|::.|          |.||.......|
Human   250 LWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVY----------HSKYKPKRLGND 304

  Fly   641 LALVKLEQPLEFAPHVSPICLPET-DSLLIGMNATVTGWGRLSEG-GTLPSVLQEVSVPIVSNDN 703
            :||:||..||.|...:.|:|||.: ::...|.....:|||...:| |....||...:||::||..
Human   305 IALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKI 369

  Fly   704 CKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFF-LAGIISWGIGCAEAN 767
            |....:..|   .|....|||||.|||.|||||||||||..  |:.|.: |.|..|:||||||.|
Human   370 CNHRDVYGG---IISPSMLCAGYLTGGVDSCQGDSGGPLVC--QERRLWKLVGATSFGIGCAEVN 429

  Fly   768 LPGVCTRISKFTPWILEHV 786
            .|||.||::.|..||.|.:
Human   430 KPGVYTRVTSFLDWIHEQM 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	99/248 (40%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	100/250 (40%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133	7/18 (39%)
		Tryp_SPc	216..444	CDD:214473	99/248 (40%)
		Tryp_SPc	217..447	CDD:238113	100/250 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740