Protein Alignment Sb and TMPRSS4

DIOPT Version :10

• Sequence 1: NP_476709.1
• Gene: Sb / 41958
• FlyBaseID: FBgn0003319
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_005271670.1
• Gene: TMPRSS4 / 56649
• HGNCID: 11878
• Length: 494
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 111/367 - (30%)
• Similarity: 169/367 - (46%)
• Gaps: 78/367 - (21%)

  Fly   447 RPTTATSSSSTST---------TSSKTPTTTRPISSSSSSSSGIVTSSQRPTQPTHRT----PVL 498
            |.|.....|:|..         |.:...|..|.:..||              :||.|.    |..
Human   110 RSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSS--------------KPTFRAVEIGPDQ 160

  Fly   499 ATSGIETNEIS------DSSIPD-AGALGHVKTISAARSECGVPTLARPETRIVGGKSAAFGRWP 556
            ....:|..|.|      :||.|. :|:|..:..::..:|      |..|  |:||.:.|:...||
Human   161 DLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKS------LKTP--RVVGVEEASVDSWP 217

  Fly   557 WQVSVRRTSFFGFSSTHRCGGALINENWIATAGHC----VDDLLISQIRIRVGEYDFSHVQEQLP 617
            ||||::      :...|.|||::::.:|:.||.||    .|   :...::|.|    |......|
Human   218 WQVSIQ------YDKQHVCGGSILDPHWVLTAAHCFRKHTD---VFNWKVRAG----SDKLGSFP 269

  Fly   618 YIERGVAKKVV---HPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLIGMNAT---VT 676
            .:  .|||.::   :|.|   ..:.|:||:||:.||.|:..|.|||||..|..|  ..||   :.
Human   270 SL--AVAKIIIIEFNPMY---PKDNDIALMKLQFPLTFSGTVRPICLPFFDEEL--TPATPLWII 327

  Fly   677 GWGRLSE-GGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGG 740
            |||...: ||.:..:|.:.||.::.:..|.:.....|.   :.:..:|||...||.|:|||||||
Human   328 GWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGE---VTEKMMCAGIPEGGVDTCQGDSGG 389

  Fly   741 PLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
            ||..:|.  ::.:.||:|||.||...:.|||.|::|.:..||
Human   390 PLMYQSD--QWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_476709.1	Tryp_SPc	544..785	CDD:238113	86/250 (34%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:470597	21/100 (21%)
		Tryp_SPc	204..429	CDD:214473	85/249 (34%)