DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and tmprss13b

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_005165399.1	Gene:	tmprss13b / 564693	ZFINID:	ZDB-GENE-090309-2	Length:	475	Species:	Danio rerio

Alignment Length:	502	Identity:	149/502 - (29%)
Similarity:	218/502 - (43%)	Gaps:	96/502 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 KPTKKPIVYD----RTPPPPPSVPPSTSTSTTSTSLIWPAQTHP--PQPH--RPTRPQ------- 387
            |.|:.|..||    :...||||.|.....|||.....:..|..|  |.||  ..|.||
Zfish     4 KQTEAPPSYDSVVTQNITPPPSYPSLQILSTTQVQPYYIPQPLPQIPAPHVVETTVPQQRTQAVS 68

  Fly   388 -------LSPGTSLAA--------------SSSSHWPSSTTSTTSSTTSTTTTTTTTRRT----T 427
                   ....|.:||              ...|.|..|.....:.|...:......|:.    :
Zfish    69 YRSKRCCYGGSTGIAAVVVLVVIAVYLGVRYGPSLWAFSERDAETDTCPGSAVNCDGRKDCSLGS 133

  Fly   428 TPTTTTRRTTTNKPTRPYQRPTTATSSS-----STSTTSSKTPTTTRPISSSSSSSSGIVTSSQR 487
            ..:...|..|.|:     .:..|:.|.|     :.....:....|.:.:....|.|.|:|.|:..
Zfish   134 DESQCVRIGTGNE-----LQVLTSRSGSFLPVCAQGWNKNIADQTCQQLGFRQSYSYGVVKSNSP 193

  Fly   488 PTQPTHRTPVLATSGIETNEISDSSIPDAGALGHVKTISAARSECGVPTLARPETRIVGGKSAAF 552
            ..|..:...|   :.|:....:.||.||.      :::|....:||.|.::   :||:||..||.
Zfish   194 MFQSVNSQLV---NNIQGRVNTSSSCPDQ------QSVSLQCCDCGRPPVS---SRIIGGSVAAE 246

  Fly   553 GRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCV-----DDLLISQIRIRVGEYDFSHV 612
            |.||||.|:.      |...|.|||:|:..::|.||.||.     ...|.|..::.:|  ..|.:
Zfish   247 GHWPWQASLH------FQGKHSCGGSLVAPDFIITAAHCFPKETSGSQLPSNWKVYIG--FVSQL 303

  Fly   613 QEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLIGM------ 671
            :...||.   |.:.::|.||:..|..||:||:||.:|   |..|.|||||     :||.
Zfish   304 KLPSPYY---VKEIILHEKYNPTTKNYDIALLKLNKP---ASDVEPICLP-----VIGQTFPPAK 357

  Fly   672 NATVTGWGRLSEG-GTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQ 735
            ....||:|.:.:| .::.:.|.||:|.::.:..|.|..:..|.   |.:...|||...||:||||
Zfish   358 QCWTTGFGVIRQGSNSVSTSLMEVTVSLIDSSVCNSPNVYNGE---ITENMQCAGDLRGGKDSCQ 419

  Fly   736 GDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
            |||||||..||.||::||.|:.|||.||.:.|.|||.:.::|:..||
Zfish   420 GDSGGPLACKSNDGQWFLTGVTSWGEGCGQVNRPGVYSDVAKYLMWI 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	95/250 (38%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	96/251 (38%)
tmprss13b	XP_005165399.1	SRCR_2	147..230	CDD:295335	17/91 (19%)
		Tryp_SPc	237..466	CDD:214473	95/250 (38%)
		Tryp_SPc	238..469	CDD:238113	96/251 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840