DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and tmprss9

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_021325244.1	Gene:	tmprss9 / 562051	ZFINID:	ZDB-GENE-050208-573	Length:	788	Species:	Danio rerio

Alignment Length:	347	Identity:	110/347 - (31%)
Similarity:	164/347 - (47%)	Gaps:	80/347 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 SGIVTSSQRPTQPTHRTPVLATSGIETNEISD--SSIPDAGALGHVKTISAARSECGVPTLARPE 541
            ||||              :|..||....||.:  |..||:       |.:....||  .|...||
Zfish   163 SGIV--------------LLGASGKSFYEIGNDISKCPDS-------TFTCDNGEC--ITKPNPE 204

  Fly   542 -------------------------TRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALIN 581
                                     .|||||::...|.:|||||:|      ....|.||.:::|
Zfish   205 CDYITDCTDGSDETFCSCGTRPVMSNRIVGGENTRHGEFPWQVSLR------LRGRHTCGASIVN 263

  Fly   582 ENWIATAGHCVD--------DLLISQIRIRVGEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYE 638
            ..|:.:|.||.:        ..|:...::...|.:...|         .:...|:.|||..:|.:
Zfish   264 SRWLVSAAHCFEVENNPKDWTALVGANQVSGAEAEAFIV---------NIKSLVMSPKYDPMTTD 319

  Fly   639 YDLALVKLEQPLEFAPHVSPICLPETDSLLI-GMNATVTGWGRLSEGGT-LPSVLQEVSVPIVSN 701
            .|:.:::||.||:|:.:|.|:|:|.:..:.. |.|..|:|||.|::..| :||.||:..|.|:.:
Zfish   320 SDVTVLELETPLKFSHYVQPVCIPSSSHVFTPGQNCIVSGWGALNQYTTEVPSTLQKAIVKIIDS 384

  Fly   702 DNC-KSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAE 765
            ..| ||...|..    :....:|||:..|..|||||||||||..:...||:|||||:|||:|||:
Zfish   385 KVCNKSSVYRGA----LTQNMMCAGFLQGKVDSCQGDSGGPLACEVAAGRYFLAGIVSWGVGCAQ 445

  Fly   766 ANLPGVCTRISKFTPWILEHVR 787
            .|.|||.:|::|...||:.:.:
Zfish   446 INKPGVYSRVTKLRNWIVSYTK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	90/249 (36%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	91/251 (36%)
tmprss9	XP_021325244.1	SEA	52..146	CDD:307516
		LDLa	185..220	CDD:238060	8/43 (19%)
		Tryp_SPc	232..462	CDD:238113	89/248 (36%)
		LDLa	510..544	CDD:238060
		Tryp_SPc	557..783	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576727
Domainoid	1	1.000	188	1.000	Domainoid score	I3236
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25354
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740