DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sb and CG7432

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_650825.2	Gene:	CG7432 / 42347	FlyBaseID:	FBgn0038727	Length:	721	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	203/780 - (26%)
Similarity:	306/780 - (39%)	Gaps:	195/780 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DSLESLGSLGIPSSSASSS----EDDDDMSSGFYRIPHRLEGYPQLQQLQRGQNFKISPKPCS-- 139
            |..||..|....||.:|.|    |||||...|      ..|.|...::...|.|..: |:..|
  Fly    63 DLAESQSSASSVSSGSSQSGSAYEDDDDDVEG------SSEYYDSDEEQSEGSNESL-PRLLSQS 120

  Fly   140 -FGRVEGTCMFVWECIKSEGKHVG-MCVD--------SFMFGSCCTHNYT-DN------IVLPQT 187
             |.|:..|...:        .||| |.||        :.|.|:..:.:.: ||      .....:
  Fly   121 TFNRISETLGAL--------NHVGHMLVDITRGGQDQAKMEGAEKSEDTSQDNSQSGGSSSATAS 177

  Fly   188 AFSYTRPTKPLTLRPRPPAAPYKPMISGMTTIERPHGAGTLVIRPSGPHHQGTLARPHPPPYQSK 252
            |.|.|......|..||..:... |.:|.......|.......:.|:|                 |
  Fly   178 ASSTTEVVPSSTSSPRGNSEQL-PGVSDKLMDPLPITLSANSLLPAG-----------------K 224

  Fly   253 PTTASDLHGSASHPSSSSSSSSSSNPNSIWHTSTQQQQQQQHQQNQQNHWQMTTEPSFITKPRPT 317
            |...|.:..:........|:     |..:.:...:.:::::..:|:|.          :.||...
  Fly   225 PANLSVIQVATKRIGMDDSA-----PMFVENKELKLKKKKKKNKNKQK----------VKKPSEE 274

  Fly   318 GWTKPGIVNLPMPARPSKPSKPTKKPIVYDRTPPPPPSVPPSTSTSTTSTSLIWPAQTHP----- 377
            |      |.:|: |:.::.|:...|          .|:.|.:|:||||:.:   |....|
  Fly   275 G------VLVPV-AQGAQQSQQKIK----------IPTTPRTTTTSTTTEA---PITLTPLDQLA 319

  Fly   378 ------------------PQPHRPTRPQLS--PGTSLAASS-------SSHWPSSTTSTTSSTTS 415
                              |...|.....||  |...|..||       .|.:........||:::
  Fly   320 EASDEAGTGKDVENYCKTPSGRRGRCEDLSSCPALLLNLSSLRESLCFKSLYVPGVCCPISSSST 384

  Fly   416 TTTTTTTTRRTTTPTTTTRRTTTNKPTRPYQ-RPTTATSSSSTSTTSSKTPTTTRPISSSSSSSS 479
            ..||....|.||.|||||..|...:||:... ||||..:|........|.||||
  Fly   385 VLTTQKPLRLTTRPTTTTSTTKATQPTKKSTVRPTTRPTSGLVLIPQKKPPTTT----------- 438

  Fly   480 GIVTSSQRPTQPTHRTPVLATSGIET--NEISDSSIPDAGALGHVKTISAARSECGVPTLARPET 542
             ..|:::.|.:|         .|::.  |.|.|   ||               |||....:  ..
  Fly   439 -TTTTTEVPLEP---------EGLDEIGNNIVD---PD---------------ECGQQEYS--TG 473

  Fly   543 RIVGGKSAAFGRWPWQVSV-----RRTSFFGFSSTHRCGGALINENWIATAGHCVDD-----LLI 597
            |||||..|..|:|||..::     :||.|:       |||:||...:|.||.||..|     ...
  Fly   474 RIVGGVEAPNGQWPWMAAIFLHGPKRTEFW-------CGGSLIGTKYILTAAHCTRDSRQKPFAA 531

  Fly   598 SQIRIRVGEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLP 662
            .|..:|:|:.|.|...|....:...|.:...|.::|.:.:..|:|::.|::|:..:.:|.|:|||
  Fly   532 RQFTVRLGDIDLSTDAEPSDPVTFAVKEVRTHERFSRIGFYNDIAILVLDKPVRKSKYVIPVCLP 596

  Fly   663 E-----TDSLLIGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFL 722
            :     ....|.|..|||.|||....||...:..::..:||..|::|...:.:.     |.:.|:
  Fly   597 KGIRMPPKERLPGRRATVVGWGTTYYGGKESTSQRQAELPIWRNEDCDRSYFQP-----INENFI 656

  Fly   723 CAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHVR 787
            ||||..||.|:|||||||||..: .|..:...|::|:|..|.|...|||.||::::..||.:|.|
  Fly   657 CAGYSDGGVDACQGDSGGPLMMR-YDSHWVQLGVVSFGNKCGEPGYPGVYTRVTEYLDWIRDHTR 720

Fly 788 787
Fly 721 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	85/253 (34%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	86/255 (34%)
CG7432	NP_650825.2	CLIP	335..378	CDD:197829	9/42 (21%)
		Tryp_SPc	474..715	CDD:214473	85/253 (34%)
		Tryp_SPc	475..718	CDD:238113	86/255 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810