DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sb and flz

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	265/1062 - (24%)
Similarity:	387/1062 - (36%)	Gaps:	381/1062 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QPTLIRPRLR-HRRSTPAAA-TKMCPKRHWLVNNRAAGSRGSGGAAARSRRSLDQIVEVLVALIV 65
            |||.:||... ::::.|.|: ..|...:|:  |.:.    |:|...|:
  Fly   724 QPTYVRPTTNANKQNRPVASYIGMVTMQHY--NPQP----GNGDYQAQ----------------- 765

  Fly    66 VNCLATAAAALITPPDSLESLGSLGIPSSSASSSEDDDDMSSGFYRIPHRLEGYPQLQQLQRGQN 130
                        .||:       :.:.|.:....|..|:.|:| |:......||
  Fly   766 ------------VPPE-------VSVSSHTTKVQEQMDETSNG-YQQSETTSGY----------- 799

  Fly   131 FKISPK---PCSFGRVEGTCMFVWECIKSEGKHVGMCVDSFMFGSCCTHNYTDNIVLPQTAFSYT 192
              :||.   |....|.:      ::.::.:..                   ::..|| .||....
  Fly   800 --VSPPTAVPAPAQRPQ------YDAVQGDAS-------------------SERPVL-VTASPRP 836

  Fly   193 RPTKPLTLR-----------------PRPPAAPY-----------KPMISGM----------TTI 219
            || ||.|.|                 |:|.|..|           ||:.:|.          ..|
  Fly   837 RP-KPSTKRPAVKRPISGESTKKKPQPQPSAGAYNQEKISEHSTRKPVSNGYDKVPESPITHIQI 900

  Fly   220 ERPHGA------GTLVIRPSGP--HHQGTLARPHP------------PPYQ----SKPTTASD-- 258
            ::|...      .|...||:.|  :.|.|.|.|.|            ||.|    |.|:.:.|
  Fly   901 KKPSATQHKEQEQTGYPRPASPAGYEQTTAAAPAPAAPSLNYDKPDAPPSQYDQPSAPSASYDQL 965

  Fly   259 -----LHGSASHPSSSSSSSSSSNPNSIWH-----TSTQQQQQQQHQQNQQNHW----------Q 303
                 |:.:..|.||.....|::.|.|..:     |.........|..|....:          |
  Fly   966 APMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDNVPPLFMADDKLDAFIQ 1030

  Fly   304 MTTE--------------------PSFITKPRPT---GWTKPGIVNL---PMPARPSK--PSKPT 340
            .|.|                    |::..:|..:   |..|||.|.:   |.|.||:.  ..|||
  Fly  1031 STAENIVGSTPGNYQPPLVATASTPAYAHRPTSSGSYGHKKPGFVQINGTPKPPRPTVLITPKPT 1095

  Fly   341 KKPIV-YDRTPPPPPSVPPSTST---------------------------------STTSTSLIW 371
            ...:| |.........:..|||:                                 |||......
  Fly  1096 AINLVTYSSLSDDSNKLASSTSSYVTGRPGVQGVSSNDFKDPGYFGSSPVHVAFTQSTTEAVYAV 1160

  Fly   372 PAQTHP-------PQPHRPT--------------------------RPQLSPGTSLAASSSS--- 400
            |:...|       |.|..|.                          .|..:|..:::|:||:
  Fly  1161 PSDDKPAFPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASSAVTS 1225

  Fly   401 -----------------------------------------HWPSS--TTST----TSSTTSTTT 418
                                                     ..|.|  |.:|    ...|.....
  Fly  1226 DLDLSTPAFVEDVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNKTVATYQAGAGGTAKPVR 1290

  Fly   419 TTTTTRRTTTPTTTTRRTTTNKPTRPYQRPTTATSSSSTSTTSSKTPTTTRPISSSSSSSSGIVT 483
            ..||.:...|.|||..:.||.||.      |..|:.:....||:.:.||.:|.:..::.::.:.|
  Fly  1291 VVTTRKPVRTATTTRPKVTTKKPV------TRVTTKAPNKKTSAVSTTTRKPATRRTTVAAKVTT 1349

  Fly   484 SSQRPT--QPTHRTPVLATSGIETNEIS-----DSSIPD-------------------------A 516
            :::||.  :||.|    .:|.::|..:|     |..|.|                         .
  Fly  1350 TTRRPATKKPTRR----VSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATLSSYG 1410

  Fly   517 GALGHVKTISAAR-------------SECGVPTLARPET---RIVGGKSAAFGRWPWQVSVRRTS 565
            ||.|. |..|.:|             :||||    ||..   ||||||.:.||.:||||.||.::
  Fly  1411 GANGR-KIHSTSRTLPTPNLAFHSPSTECGV----RPHVKSGRIVGGKGSTFGAYPWQVLVREST 1470

  Fly   566 FFGFSSTHRCGGALINENWIATAGHCVDDLLISQIRIRVGEYDFSHVQEQLPYIERGVAKKVVHP 630
            :.|..:.::|||.||...::.||.||....|.|.:.: :||:|.|...|....:.:.|.:.:||.
  Fly  1471 WLGLFTKNKCGGVLITSRYVITAAHCQPGFLASLVAV-MGEFDISGDLESKRSVTKNVKRVIVHR 1534

  Fly   631 KYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLIGMNATVTGWGRLSEGGTLPSVLQEVS 695
            :|...|:|.||||::|:.|::|..|:.|||:|...:...|..|||||||||..||.:|||||||.
  Fly  1535 QYDPATFENDLALLELDSPVQFDTHIVPICMPNDVADFTGRMATVTGWGRLKYGGGVPSVLQEVQ 1599

  Fly   696 VPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWG 760
            |||:.|..|:.||..||..:.|...||||||..|.:|||:|||||||..:..|||:.|||.:|.|
  Fly  1600 VPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHG 1664

  Fly   761 IGCAEANLPGVCTRISKFTPWI 782
            |.||...||||..|.:.:.||:
  Fly  1665 IKCAAPYLPGVYMRTTFYKPWL 1686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	112/238 (47%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	112/239 (47%)
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669	69/363 (19%)
		PHA03247	<792..1096	CDD:223021	66/343 (19%)
		Tryp_SPc	1449..1689	CDD:238113	112/239 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3236
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D75559at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25354
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020