DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	254	Identity:	93/254 - (36%)
Similarity:	131/254 - (51%)	Gaps:	29/254 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 RIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQ---IRIRV 604
            ||:||.....|.||||||:.      |..:..||.::|:..|:.:|.||.....:|.   ....:
Human   605 RIIGGTDTLEGGWPWQVSLH------FVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHL 663

  Fly   605 GEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLE--QPLEFAPHVSPICLPET-DS 666
            |.|    ||....::. .|.:.|||..|:..|::||:||::|.  .|......:.|||:|.| ..
Human   664 GMY----VQGNAKFVS-PVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQR 723

  Fly   667 LLIGMNATVTGWGRLSEG---GTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYET 728
            :..|....||||||..|.   |:|  |||:..|.::....|.|.:      ..|....||||..:
Human   724 VRSGEKCWVTGWGRRHEADNKGSL--VLQQAEVELIDQTLCVSTY------GIITSRMLCAGIMS 780

  Fly   729 GGQDSCQGDSGGPLQA-KSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHV 786
            |.:|:|:|||||||.. :..||::.|.||:|||.|....|.|||.||:|.|.|||.::|
Human   781 GKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYV 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	90/248 (36%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	91/250 (36%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840