DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and OVCH1

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_024304736.1	Gene:	OVCH1 / 341350	HGNCID:	23080	Length:	1120	Species:	Homo sapiens

Alignment Length:	302	Identity:	107/302 - (35%)
Similarity:	158/302 - (52%)	Gaps:	34/302 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 RTPVLATSGIETNEISDSSIPDAGALGHVKTISAARSECGVPTLARPE---TRIVGGKSAAFGRW 555
            |..:|.:..:  |:......|....:..||.|  ....||:|..: |:   .||.||:.|....|
Human   562 RFTILPSESL--NKFEPKLPPQNNPVSTVKAI--LHDVCGIPPFS-PQWLSRRIAGGEEACPHCW 621

  Fly   556 PWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQIR-------IRVGEYDFSHVQ 613
            ||||.:|      |...::||||:||..||.||.|||      |::       |..|::| .:::
Human   622 PWQVGLR------FLGDYQCGGAIINPVWILTAAHCV------QLKNNPLSWTIIAGDHD-RNLK 673

  Fly   614 EQLPYIERGVAKK-VVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPET-DSLLIGMNATVT 676
            |....:.|  ||. :||..::.|:|:.|:||::|..|||:...|.|:|||.: :.|.......||
Human   674 ESTEQVRR--AKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSEICAVT 736

  Fly   677 GWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQ-DSCQGDSGG 740
            |||.:|..|.|.|.||::.|.::..:.|:..:..| ....|.:..:|||:...|: |.|||||||
Human   737 GWGSISADGGLASRLQQIQVHVLEREVCEHTYYSA-HPGGITEKMICAGFAASGEKDFCQGDSGG 800

  Fly   741 PLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
            ||..:.::|.|.|.||:|||.||.:...|||..|:..|..||
Human   801 PLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWI 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	94/248 (38%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	95/249 (38%)
OVCH1	XP_024304736.1	Tryp_SPc	58..294	CDD:238113
		CUB	336..444	CDD:238001
		CUB	454..565	CDD:238001	1/2 (50%)
		Tryp_SPc	610..845	CDD:238113	95/249 (38%)
		CUB	881..978	CDD:238001
		CUB	1017..1119	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910