DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and TMPRSS11A

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_872412.3	Gene:	TMPRSS11A / 339967	HGNCID:	27954	Length:	421	Species:	Homo sapiens

Alignment Length:	295	Identity:	94/295 - (31%)
Similarity:	146/295 - (49%)	Gaps:	41/295 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 PVLATSGIETNEISDSSIPDAGALGHVKTISAARSECGVPTLARPETRIVGGKSAAFGRWPWQVS 560
            |:.|:| ::.|.:|.|:    |.|    |:.|:   ||...:.....||..|..|....||||.|
Human   154 PINASS-VQVNAMSSST----GEL----TVQAS---CGKRVVPLNVNRIASGVIAPKAAWPWQAS 206

  Fly   561 VRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQIRIRVGEYDFSH-------VQEQLPY 618
            ::      :.:.|:||..||:..|:.||.||..            :|...|       .:...|.
Human   207 LQ------YDNIHQCGATLISNTWLVTAAHCFQ------------KYKNPHQWTVSFGTKINPPL 253

  Fly   619 IERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETD-SLLIGMNATVTGWGRLS 682
            ::|.|.:.::|.||.....|||:|:|::...:.|:..:..|||||.. |....:...:||:|.|.
Human   254 MKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASFQPNLTVHITGFGALY 318

  Fly   683 EGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQ 747
            .||...:.|:|..|.|:|:|.||.  .:....:..|.:| ||||..|..|:|:|||||||..:..
Human   319 YGGESQNDLREARVKIISDDVCKQ--PQVYGNDIKPGMF-CAGYMEGIYDACRGDSGGPLVTRDL 380

  Fly   748 DGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
            ...::|.||:|||..|.:.:.|||.|:::.:..||
Human   381 KDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWI 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	80/246 (33%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	81/247 (33%)
TMPRSS11A	NP_872412.3	SEA	49..147	CDD:279699
		Tryp_SPc	189..415	CDD:214473	80/246 (33%)
		Tryp_SPc	190..418	CDD:238113	81/247 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840