DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sb and plg

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_958880.2	Gene:	plg / 322691	ZFINID:	ZDB-GENE-030131-1411	Length:	818	Species:	Danio rerio

Alignment Length:	828	Identity:	203/828 - (24%)
Similarity:	288/828 - (34%)	Gaps:	254/828 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 VWECIKSEGKHVGMCVDSFMF----GSCCT---HNYTDNIVLPQTAFSYTRPTKPLTLRPRPPAA 207
            |.||.....|.|.....||::    ..|.|   ::.||.|:...:|..|.:  |...|.
Zfish    53 VEECAVKCNKEVSFTCRSFLYIEKDQDCVTLPANSKTDQILRRMSAALYEK--KEYLLE------ 109

  Fly   208 PYKPMISGMTTIERPHGAGTLVIRPSG---PHHQGTLARPHPPPYQSKPTTASDLHGSASHPSSS 269
                .::|:....|    ||.....||   ...:||.  ||.|....:           ::|.:.
Zfish   110 ----CVNGIGMDYR----GTKSKTKSGKTCQRWEGTF--PHVPNITPR-----------AYPKAD 153

  Fly   270 SSSSSSSNPN----SIWHTSTQQQQQQQH-----------------------------------Q 295
            ..|:...||:    ..|..:|..:::.:|                                   .
Zfish   154 LESNFCRNPDGDKGGPWCYTTDPEKRWEHCNIQDCTEECMQCSGENYRGKISTTVSGFTCQRWDS 218

  Fly   296 QNQQNH--------------------------WQMTTEPS----------FITKPRPT------- 317
            |..|||                          |..||.||          ..|:| ||
Zfish   219 QQPQNHGYLPSALPDKYLEENYCRNPDGEPRPWCFTTSPSKRWEACAIPRCTTEP-PTIVPELTC 282

  Fly   318 ----GWTKPGIVNLPMPAR------PSKPSKPTKKPIVY-----DRTPPPPPSVPPSTSTSTTST 367
                |.:..|.:::.:..:      ...|.|.::.|..|     |......|....|....||..
Zfish   283 ASGEGSSYRGTISVTITGKTCQQWTSQSPHKHSRSPENYPCKGLDGNYCRNPDNERSPWCYTTDP 347

  Fly   368 SLIW-----PAQTHPPQPHRPTRPQ-----LSPGTS--------LAASSSSHWPSSTTSTTSSTT 414
            ...|     |:....|:|..|..||     ...|:|        ::......|.|......|.|.
Zfish   348 ETRWEYCSVPSCGDQPRPEEPVIPQGEECYEGDGSSYRGVMSETISGKKCQFWTSMEPHRHSKTP 412

  Fly   415 STTTTTTTTRR--------------TTTPTTTTR----RTTTNKPT--RPYQRPTTATSSSSTST 459
            .........|.              ||.||....    ....|:|.  .|..:|...|.:.||..
Zfish   413 QNFPKADLRRNLCRNPDGDRAPWCYTTDPTVRWEYCNIERCDNRPNIQEPPAKPAATTPTQSTPA 477

  Fly   460 TSSKTPTTTRPI-------------SSSSSSSSGIVTSSQR---PTQPTHRTP-VLATSGIETNE 507
            .|  ||..:.|.             .|:|.:..|:...:.|   |.|....|| .....|:|:|:
Zfish   478 QS--TPDQSAPSEKDCKNGNGAEYRGSTSMTVMGVTCQAWRSMTPHQHASFTPETHPDKGLESNQ 540

  Fly   508 --------------ISDSS-------IPDAGALGHVKTISAARSECGVPTLARPET---RIVGGK 548
                          .:|.|       |||..:|           :||.|. .:|:.   |||||.
Zfish   541 CRNPDSDVNGPWCYTTDPSKKWDYCQIPDCESL-----------KCGQPA-TKPKRCFGRIVGGC 593

  Fly   549 SAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCV---DDLLISQIRIRVGEYDFS 610
            .:....||||:|:|..     ...|.|||.||:..|:.||.||:   |.....:|.:.:.....:
Zfish   594 VSKPHSWPWQISLRTR-----GKIHFCGGTLIDPQWVVTAAHCLERSDSPSAYKIMLGIHTERAT 653

  Fly   611 HVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLL-IGMNAT 674
            ...:|    ||.|.|.:..|..:      |:||:||::|......|||:||||.|.:: ......
Zfish   654 ESSKQ----ERDVTKIIKGPAGT------DIALLKLDRPALINDKVSPVCLPEKDYIVPSNTECY 708

  Fly   675 VTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSG 739
            |||||...:.|. ...|:|...|::.|..|.......||   :.|..:|||...||.||||||||
Zfish   709 VTGWGETQDTGG-EGYLKETGFPVIENKVCNRPSFLNGR---VKDHEMCAGNIEGGNDSCQGDSG 769

  Fly   740 GPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHVR 787
            |||...:|: .|.|.|:.|||:|||.|..|||.||:|||..||...::
Zfish   770 GPLVCYAQN-TFVLQGVTSWGLGCANAMKPGVYTRVSKFVDWIERSIK 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	93/242 (38%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	94/244 (39%)
plg	NP_958880.2	PAN_AP_HGF	31..104	CDD:238532	14/52 (27%)
		KR	109..190	CDD:214527	18/107 (17%)
		KR	190..270	CDD:214527	9/79 (11%)
		KR	281..361	CDD:214527	13/79 (16%)
		Kringle	376..453	CDD:306546	11/76 (14%)
		KR	490..572	CDD:214527	16/81 (20%)
		Tryp_SPc	589..813	CDD:238113	94/243 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4203
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960