DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	266	Identity:	97/266 - (36%)
Similarity:	141/266 - (53%)	Gaps:	40/266 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 ECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDDL 595
            :||   |..|.:|||||..::.|.||||.|::      ....|.||||||.:.|:.||.||..:.
  Rat   567 DCG---LQGPSSRIVGGAMSSEGEWPWQASLQ------IRGRHICGGALIADRWVITAAHCFQED 622

  Fly   596 LISQIRIRV-------------GEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLE 647
            .::..|:..             ||..|.            |::..:||.:...:::||:||::|:
  Rat   623 SMASPRLWTVFLGKMRQNSRWPGEVSFK------------VSRLFLHPYHEEDSHDYDVALLQLD 675

  Fly   648 QPLEFAPHVSPICLPETDSLL-IGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRA 711
            .|:.::..|.|:|||...... .|.:..:||||...|||...|.||:|.|.::..|.|...:
  Rat   676 HPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAY--- 737

  Fly   712 GRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRIS 776
             |.:..|.: |||||..|.:|:|||||||||..|...||:||||::|||:||...|..||.||::
  Rat   738 -RYQVTPRM-LCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVT 800

  Fly   777 KFTPWI 782
            :...||
  Rat   801 RVVNWI 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	91/252 (36%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	92/253 (36%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	91/252 (36%)
		Tryp_SPc	577..809	CDD:238113	92/253 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740