DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and TMPRSS11E

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_054777.2	Gene:	TMPRSS11E / 28983	HGNCID:	24465	Length:	423	Species:	Homo sapiens

Alignment Length:	283	Identity:	88/283 - (31%)
Similarity:	133/283 - (46%)	Gaps:	49/283 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 VKTISAARSE------CGV---PTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGG 577
            :|.|:...::      ||.   .||.: ..|||||.....|.||||.|::      :..:||||.
Human   162 IKKINKTETDSYLNHCCGTRRSKTLGQ-SLRIVGGTEVEEGEWPWQASLQ------WDGSHRCGA 219

  Fly   578 ALINENWIATAGHCVDDLLISQIRIRVGEYDFSHVQEQLPY------------IERGVAKKVVHP 630
            .|||..|:.:|.||                 |:..:....:            ::||:.:.:||.
Human   220 TLINATWLVSAAHC-----------------FTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHE 267

  Fly   631 KYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETD-SLLIGMNATVTGWGRLSEGGTLPSVLQEV 694
            ||...:::||::|.:|..|:.:...|..:|||:.. ....|....|||:|.|...|...:.|::.
Human   268 KYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQA 332

  Fly   695 SVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISW 759
            .|.::....|..  .:|......|.: ||||...|..|:|||||||||.:......::||||:||
Human   333 QVTLIDATTCNE--PQAYNDAITPRM-LCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSW 394

  Fly   760 GIGCAEANLPGVCTRISKFTPWI 782
            |..||:.|.|||.||::....||
Human   395 GDECAKPNKPGVYTRVTALRDWI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	80/251 (32%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	81/252 (32%)
TMPRSS11E	NP_054777.2	SEA	51..156	CDD:307516
TMPRSS11E	NP_054777.2	Tryp_SPc	192..420	CDD:238113	81/252 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840