DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sb and Tmprss7

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001099352.2	Gene:	Tmprss7 / 288118	RGDID:	1304655	Length:	829	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	180/795 - (22%)
Similarity:	290/795 - (36%)	Gaps:	214/795 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 EVLVALIVVNCLATAAAALITPPDSLESLGSLGIPSSSA----------SSSEDDDDMSSGFYRI 112
            |..||.|:.:.:.|:    ||...|:.:|..|.:...|.          ||:...|:..|.::..
  Rat   179 EECVAAILKDSIQTS----ITNRTSVGTLQGLAVDMDSVVLNAGLRSDYSSAVGSDNGCSQYFYA 239

  Fly   113 PHRLEGYPQLQQLQRGQNFKISPKPCSFGRVEGTCMFVWECIKSEGKHVGMCVDSFMF--GSCCT 175
            .|....||          .:||       ...|..|..::.:...|..:.:.::|...  .:|.|
  Rat   240 DHLTLRYP----------LEIS-------ATSGQLMCHFKLVAIVGYLIRLSIESIQLEADNCIT 287

  Fly   176 HNYT--DNIVLPQTAFSY--TRPTKPL------------TLRPRPPAAPYKPMISGM----TTIE 220
            .:.|  |:::..::|..|  ..||:.|            ||:     :||...::|:    ..|.
  Rat   288 DSLTVYDSLLPIRSAILYRICEPTRTLMSFVSTNNLMLVTLK-----SPYVRRLAGIRAYFEVIP 347

  Fly   221 RPHGAGTLVIRPSGPHHQGTLARPHPPPYQ--------SKPTTASDLHGSA--SHPSSSSSSSSS 275
            ......|::::... ..:|.::.|:.|.|.        :..|:.|.| |.|  .|..|.:..|..
  Rat   348 EQKCENTILVKEIN-SFEGKISSPYYPSYYPPKCKCNWTFQTSLSTL-GIALKFHNYSITKKSMK 410

  Fly   276 SNPNSIWHTSTQQQQQQQHQQNQQNHWQMTTEPSFITKPRPTGWTKPGIVNLPMPARPSKPSKPT 340
            ...:..|..:     :..:..:..:|..:...||             .:|::.:..    .|:.:
  Rat   411 GCEHGWWEIN-----EHMYCGSYMDHETIFRVPS-------------PLVHIQLQC----SSRLS 453

  Fly   341 KKPIV-----YDRTPPPPPSVPPSTSTSTTSTSLIWPAQTHPPQPHRPTRPQLSPGTSLAASSSS 400
            .||::     |:.:.|.|      ..:...|:.|..|            :.|...|.:.....|.
  Rat   454 DKPLLVEYGSYNISQPCP------AGSFRCSSGLCVP------------QAQRCDGVNDCFDESD 500

  Fly   401 HWPSSTTSTTSSTTSTTTTTTTTRRTTTPTTTTRRTTTNKPTRPYQRPTTATSSSSTSTTSSKTP 465
            .        ....|:.....|:..|...|....          .:|   ...........:...|
  Rat   501 E--------LFCVTAKPACNTSIFRQHGPLVCD----------GFQ---DCEDGQDEQNCTRSIP 544

  Fly   466 TTTRPIS--------SSSSSSSGIVTSSQRPTQPTHRTPVLATSGIETNEISDSSIPDAGALGHV 522
            .|.|...        ..::...|||                             ..||
  Rat   545 CTNRTFKCGNDICFRKQNAQCDGIV-----------------------------DCPD------- 573

  Fly   523 KTISAARSE---CGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENW 584
                  ||:   ||....:....|:|||..:..|.||||||:.   |.|  |.| ||.::|:..|
  Rat   574 ------RSDEEGCGCSRSSPFLHRVVGGSDSQEGTWPWQVSLH---FVG--SAH-CGASVISREW 626

  Fly   585 IATAGHCVDDLLISQ---IRIRVGEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKL 646
            :.:|.||.....:|.   ....:|.|    ||....::. .|.:.|||..|:..|::||:||::|
  Rat   627 LLSAAHCFHGNRLSDPTPWTAHLGMY----VQGNAKFVS-PVRRIVVHEYYNSQTFDYDIALLQL 686

  Fly   647 E--QPLEFAPHVSPICLPET-DSLLIGMNATVTGWGRLSEGGTLPS-VLQEVSVPIVSNDNCKSM 707
            .  .|......:.|||:|.. ..:..|....||||||..|..:..| :||:..|.::....|.|.
  Rat   687 SIAWPETLRQLIQPICIPPVGQRVRSGEKCWVTGWGRRHEADSKGSPILQQAEVELIDQTVCVST 751

  Fly   708 FMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQA-KSQDGRFFLAGIISWGIGCAEANLPGV 771
            :      ..|....||||..:|..|:|:|||||||.. :..||::.|.||:|||.||...|.|||
  Rat   752 Y------GIITSRMLCAGVMSGKSDACKGDSGGPLSCRRKSDGKWILTGIVSWGYGCGRPNFPGV 810

  Fly   772 CTRISKFTPWILEHV 786
            .||:|.|.|||.::|
  Rat   811 YTRVSNFVPWIHKYV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	91/246 (37%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	92/248 (37%)
Tmprss7	NP_001099352.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		SEA	94..190	CDD:279699	4/10 (40%)
		CUB	<257..345	CDD:238001	17/92 (18%)
		LDLa	470..504	CDD:238060	7/59 (12%)
		LDLa	545..580	CDD:238060	9/76 (12%)
		Tryp_SPc	591..821	CDD:214473	91/246 (37%)
		Tryp_SPc	592..823	CDD:238113	92/247 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337549
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930