DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and Klkb1

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_036857.2	Gene:	Klkb1 / 25048	RGDID:	67382	Length:	638	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	120/379 - (31%)
Similarity:	178/379 - (46%)	Gaps:	65/379 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 KTPTTTRP----ISSSSSSSSGIVTSSQRPTQPTHRTPVLATSGIETNEISDSSIPDAGALGH-- 521
            ||..:.||    |..::.|...:.|..:...:|.| ..:.:....|..|::.:.:..|.|...
  Rat   259 KTSKSGRPSPPIIQENAVSGYSLFTCRKARPEPCH-FKIYSGVAFEGEELNATFVQGADACQETC 322

  Fly   522 VKTI-------SAARSEC--------------GVPT-------------------------LARP 540
            .|||       |....:|              |.||                         ..:.
  Rat   323 TKTIRCQFFTYSLLPQDCKAEGCKCSLRLSTDGSPTRITYEAQGSSGYSLRLCKVVESSDCTTKI 387

  Fly   541 ETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQI-RIRV 604
            ..|||||.:::.|.||||||::...   .|..|.|||::|...||.||.||.|.:....: ||..
  Rat   388 NARIVGGTNSSLGEWPWQVSLQVKL---VSQNHMCGGSIIGRQWILTAAHCFDGIPYPDVWRIYG 449

  Fly   605 GEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLP-ETDSLL 668
            |..:.|.:..:.|:  ..:.:.::|.||......||:||:||:.||.:.....||||| :.|:..
  Rat   450 GILNLSEITNKTPF--SSIKELIIHQKYKMSEGSYDIALIKLQTPLNYTEFQKPICLPSKADTNT 512

  Fly   669 IGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDS 733
            |..|..|||||...|.|...::||:.::|:|.|:.|:..:    |...|....:||||:.||.|:
  Rat   513 IYTNCWVTGWGYTKERGETQNILQKATIPLVPNEECQKKY----RDYVITKQMICAGYKEGGIDA 573

  Fly   734 CQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHVR 787
            |:|||||||..| ..||:.|.||.|||.|||....|||.|:::::..||||.::
  Rat   574 CKGDSGGPLVCK-HSGRWQLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQ 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	95/240 (40%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	97/242 (40%)
Klkb1	NP_036857.2	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	201..284	CDD:128519	6/24 (25%)
		APPLE	292..375	CDD:128519	13/83 (16%)
		Tryp_SPc	390..621	CDD:214473	95/240 (40%)
		Tryp_SPc	391..621	CDD:238113	94/239 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44824
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810