DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and Tmprss15

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_032967.1	Gene:	Tmprss15 / 19146	MGIID:	1197523	Length:	1069	Species:	Mus musculus

Alignment Length:	681	Identity:	175/681 - (25%)
Similarity:	269/681 - (39%)	Gaps:	152/681 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 FMFGSCCTHNY-----------TDNIVLPQTAFSYTRPTK--PLTLRPRPPAAPYKPMISGMTTI 219
            |.:..||.:.|           ||.||. |...:|.|...  .:||.   ....:|.:.:..
Mouse   470 FWYYMCCENVYNLNIHISSAETTDKIVF-QRKGNYGRNWNYGQVTLN---ETGEFKVVFNAF--- 527

  Fly   220 ERPHGAGTLV---------IRPSGPHHQGTLARPHPPPYQSKPTTASDLHGSAS--HPSSSSSSS 273
             |..|..|:.         |....|:.:.||. |.|||  ..||   |..|...  .|:|:.||.
Mouse   528 -RNRGCSTIALDDISLTNGICSQSPYPEPTLV-PTPPP--ELPT---DCGGPFELWEPNSTFSSP 585

  Fly   274 S--SSNPNS---IWHTSTQQQQQQQHQQNQQNHWQMTTEPSF--ITKPRPTG---------WTKP 322
            :  ...||.   ||:.:.|:      .:|.|.|:|.....:.  :.:.|..|         :|.|
Mouse   586 NFPDKYPNQASCIWNLNAQR------GKNIQLHFQEFDLENINDVVEVRDGGEFDSLLLAVYTGP 644

  Fly   323 GIVNLPMPARPSKP--SKPTKKPIVYDRTPPPPPSVPPSTSTSTTSTSLIWPAQTHPPQPHRPTR 385
            |         |.|.  |...:..:::............:..||.....:        |:|.:...
Mouse   645 G---------PVKDLFSTTNRMTVIFTTNMETRRKGFKANFTSGYYLGI--------PEPCQDDE 692

  Fly   386 PQLSPGTSLAASS-SSHWPSSTTSTTSSTTSTTTTTTTTRRTTTPTTTTRRTTTNKPTRPY---- 445
            .|...|..:...: ...:|.....  |...|.......||             :|.....:
Mouse   693 FQCKDGNCIPLGNLCDSYPHCRDG--SDEASCVRFLNGTR-------------SNNGLVQFNIHS 742

  Fly   446 -------QRPTTATSSSSTSTTSSKTPTTTRPISSSSSSSSGIVTSSQRPTQPTHRTPVLATSGI 503
                   :..||..|:.........:..::.||||:....  .|..:|.|......||.|..|
Mouse   743 IWHIACAENWTTQISNEVCHLLGLGSANSSMPISSTGGGP--FVRVNQAPNGSLILTPSLQCS-- 803

  Fly   504 ETNEISDSSIPDAGALGHVKTISAARSECGVPTLA-RPETRIVGGKSAAFGRWPWQVSVRRTSFF 567
                 .||.|          .:......||...:. :...:||||..|..|.|||.|::    :.
Mouse   804 -----QDSLI----------LLQCNHKSCGEKKVTQKVSPKIVGGSDAQAGAWPWVVAL----YH 849

  Fly   568 GFSSTHR--CGGALINENWIATAGHCVDDLLISQIR--IRVGEYDFSHVQEQL--PYIERGVAKK 626
            ...||.|  ||.:|::.:|:.:|.|||....:...|  ..:|    .|:|..|  |.:.|.|..:
Mouse   850 RDRSTDRLLCGASLVSSDWLVSAAHCVYRRNLDPTRWTAVLG----LHMQSNLTSPQVVRRVVDQ 910

  Fly   627 -VVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLI-GMNATVTGWG--RLSEGGTL 687
             |::|.|.......|:|::.||..:.:..::.||||||.:.:.| |...::.|||  :::.|.|:
Mouse   911 IVINPHYDRRRKVNDIAMMHLEFKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYDKINAGSTV 975

  Fly   688 PSVLQEVSVPIVSNDNCKSMFMRAGRQEF-IPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRF 751
             .||:|..||::||:.|:...     .|: |.:..:|||||.||.|||||||||||..: ::.|:
Mouse   976 -DVLKEADVPLISNEKCQQQL-----PEYNITESMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRW 1033

  Fly   752 FLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
            ||.|:.|:|:.||..|.|||..|:|:|..||
Mouse  1034 FLVGVTSFGVQCALPNHPGVYVRVSQFIEWI 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	92/249 (37%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	94/250 (38%)
Tmprss15	NP_032967.1	SEA	53..154	CDD:214554
		LDLa	228..261	CDD:197566
		CUB	270..376	CDD:294042
		MAM	392..549	CDD:279023	18/86 (21%)
		MAM	392..547	CDD:99706	17/84 (20%)
		CUB	569..676	CDD:278839	22/121 (18%)
		LDLa	688..722	CDD:238060	4/35 (11%)
		SR	723..816	CDD:214555	20/124 (16%)
		SRCR	728..819	CDD:278931	21/122 (17%)
		Tryp_SPc	829..1064	CDD:214473	92/249 (37%)
		Tryp_SPc	830..1066	CDD:238113	94/250 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740