DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sb and svh-1

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_501379.2	Gene:	svh-1 / 182375	WormBaseID:	WBGene00006620	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	137/502 - (27%)
Similarity:	205/502 - (40%)	Gaps:	117/502 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 PPSTSTSTTSTSLIWPAQTHPPQPHRPTRPQL-SPGTSLAASSSSHWPSSTTSTTSSTTSTTTTT 420
            |..|..|..|.|.:.|.|   |....||.|.. ||      ||.|....::.|.|.:........
Worm   482 PIYTVESHQSESSLGPLQ---PTTLHPTNPSFDSP------SSVSQMRRTSPSATLAPRLPAWNL 537

  Fly   421 TTTRRTTTPTTTTRRTTTNKPTR---------------------------------PYQRPTT-- 450
            :..|.   |..|:...:|.:|.|                                 .|.|..:
Worm   538 SCLRE---PNCTSTVISTCEPIRCSHCQQAACGDGSCIRFDQLCNGQIDCQSGEDEDYCRANSFR 599

  Fly   451 ATSSSSTS------TTSSKTPTTTRPISSSSSSS---------SGIVTSSQRPTQPTHRTPVLAT 500
            .|:.|.||      ..|...|.....::...|:|         .|.:.|          |....:
Worm   600 LTNGSDTSGYLEVLFRSRWEPICADHLNGKISNSICDAMRLGEHGFILS----------TNATIS 654

  Fly   501 SGIETNEISDSSIPDAGALGHVKTIS-------AARSECG---VPTLARPE-----TRIVGGKSA 550
            ||...|...|.||..:.:......||       ::.|:||   |...||..     .|:|||...
Worm   655 SGYNVNCDVDCSIRRSSSCTRHARISCISQNGMSSASQCGLRYVEVNARDAAKSRIARVVGGFET 719

  Fly   551 AFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCV-DDLLISQIRIRVGEYDFSHV-- 612
            ..|.:||..::|..:    :..|.||.:::::..:.||.||. :|..:|...:.||::|.:..
Worm   720 VPGAFPWTAALRNKA----TKAHHCGASILDKTHLITAAHCFEEDERVSSYEVVVGDWDNNQTDG 780

  Fly   613 QEQLPYIERGVAKKVVH--PKYSFLTYEYDLALVKLEQP-LEFAPHVSPICLPETDSLLI-GMNA 673
            .||:.|::|      :|  |.|..: :.:|:|::::..| :||..:..|||||..|.:.. |...
Worm   781 NEQIFYLQR------IHFYPLYKDI-FSHDIAILEIPYPGIEFNEYAQPICLPSKDFVYTPGRQC 838

  Fly   674 TVTGWGRLSEGGTLPSVLQEVSVPIVSNDNC---KSMFMRAGRQEFIPDIFLCAGYETGGQDSCQ 735
            .|:|||  |.|......||...:||::..:|   ..::....|..|      ||||..||.||||
Worm   839 VVSGWG--SMGLRYAERLQAALIPIINRFDCVNSSQIYSSMSRSAF------CAGYLEGGIDSCQ 895

  Fly   736 GDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
            ||||||...:.:||.|.|||:||||.|||:...||:.|.::.:..||
Worm   896 GDSGGPFACRREDGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWI 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	84/248 (34%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	85/249 (34%)
svh-1	NP_501379.2	KR	227..306	CDD:214527
		LDLa	320..355	CDD:238060
		PAN_AP_HGF	373..434	CDD:238532
		LDLa	558..590	CDD:197566	0/31 (0%)
		SRCR_2	599..681	CDD:382996	18/91 (20%)
		Tryp_SPc	713..945	CDD:238113	85/249 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910