DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	292	Identity:	100/292 - (34%)
Similarity:	147/292 - (50%)	Gaps:	62/292 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 ECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCV-DD 594
            :||   |..|.:|||||..::.|.||||.|::      ....|.||||||.:.|:.||.||. :|
Human   558 DCG---LQGPSSRIVGGAVSSEGEWPWQASLQ------VRGRHICGGALIADRWVITAAHCFQED 613

  Fly   595 LLISQIRIRV------------GEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLE 647
            .:.|.:...|            ||..|.            |::.::||.:...:::||:||::|:
Human   614 SMASTVLWTVFLGKVWQNSRWPGEVSFK------------VSRLLLHPYHEEDSHDYDVALLQLD 666

  Fly   648 QPLEFAPHVSPICLPETDSLL-IGMNATVTGWGRLSEGG----------------------TLPS 689
            .|:..:..|.|:|||...... .|::..:||||.|.||.                      .:.:
Human   667 HPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISN 731

  Fly   690 VLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLA 754
            .||:|.|.::..|.|..::    |.:..|.: |||||..|.:|:|||||||||..|:..||:|||
Human   732 ALQKVDVQLIPQDLCSEVY----RYQVTPRM-LCAGYRKGKKDACQGDSGGPLVCKALSGRWFLA 791

  Fly   755 GIISWGIGCAEANLPGVCTRISKFTPWILEHV 786
            |::|||:||...|..||.|||:....||.:.|
Human   792 GLVSWGLGCGRPNYFGVYTRITGVISWIQQVV 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	93/274 (34%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	94/276 (34%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	94/276 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740