DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and Tmprss2

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_008766769.1	Gene:	Tmprss2 / 156435	RGDID:	620766	Length:	580	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	150/539 - (27%)
Similarity:	218/539 - (40%)	Gaps:	117/539 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 QNHWQMTTEPSFITKPRPTGWTKPGIVNLPMPARPSKPSKPTKKPIVYDRTPPPPPSVPPSTS-- 361
            :||..   :...:..|||.  ..|...|| .||:......|...|.|..:...|...:.|.:|
  Rat    16 ENHGY---QSEHVYSPRPP--VSPSGYNL-YPAQSCPSPVPQYAPRVTTQASTPAIHIQPRSSGT 74

  Fly   362 --TSTTSTSLIWPAQTHPPQPHRPTRPQLSPGTSLAASSSS------HWPSSTTSTTSSTTSTTT 418
              ||.:..|::               ..|:.||.||.::.:      .|.|..:|:.....|:.|
  Rat    75 LCTSKSKKSML---------------VALALGTVLAGAAVAAGLLWKFWDSKCSSSEMECGSSGT 124

  Fly   419 TTTTTRRTTTPTTTTRRTTTNKPTRPYQRPTTATSSSSTSTTSSKTPTTTRPISSSSSSSSGIVT 483
            ..:::......:........|:..|.|          .||.|..                   |.
  Rat   125 CISSSLWCDGVSQCPNGEDENRCVRLY----------GTSFTLQ-------------------VY 160

  Fly   484 SSQRPT---------QPTHRTPVLATSGIETNEISDSSIPD-AGALGHVK--------------- 523
            ||||..         ..::........|.:.:..|...||| :||...:|
  Rat   161 SSQRKAWYPVCQDDWNESYGRAACKDMGYKNSFYSSQGIPDQSGATSFMKLNVSAGNVDLYKKLY 225

  Fly   524 ---------TISAARSECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGAL 579
                     .:|....||||.::.| ::|||||.:|:.|.||||||:.      ....|.|||::
  Rat   226 HSDSCSSRMVVSLRCIECGVRSVRR-QSRIVGGSTASPGDWPWQVSLH------VQGIHVCGGSI 283

  Fly   580 INENWIATAGHCVDDLLISQIRIRVGEY--DFSHVQEQ--LPYIERGVAKKVV-HPKYSFLTYEY 639
            |...||.||.|||::.|.|.      .|  .|:.:.:|  :.|..|...:||: ||.|...|...
  Rat   284 ITPEWIVTAAHCVEEPLSSP------RYWTAFAGILKQSLMFYGSRHQVEKVISHPNYDSKTKNN 342

  Fly   640 DLALVKLEQPLEFAPHVSPICLPETDSLL-IGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDN 703
            |:||:||:.||.|...|.|:|||....:| :.....::|||...|.|....||....||::....
  Rat   343 DIALMKLQTPLAFNDVVKPVCLPNPGMMLDLAQECWISGWGATYEKGKTSDVLNAAMVPLIEPSK 407

  Fly   704 CKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANL 768
            |.|.::   ....|....:|||:..|..|||||||||||.....: .::|.|..|||.|||:|..
  Rat   408 CNSKYI---YNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLKNE-IWWLIGDTSWGSGCAKAYR 468

  Fly   769 PGVCTRISKFTPWILEHVR 787
            |||...::.||.||.:.:|
  Rat   469 PGVYGNVTVFTDWIYQQMR 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	93/244 (38%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	94/246 (38%)
Tmprss2	XP_008766769.1	LDLa	112..147	CDD:238060	4/34 (12%)
		SRCR_2	152..247	CDD:292133	21/113 (19%)
		Tryp_SPc	253..482	CDD:214473	93/244 (38%)
		Tryp_SPc	254..485	CDD:238113	94/246 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44824
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740