DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and Tmprss3

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001157248.1	Gene:	Tmprss3 / 140765	MGIID:	2155445	Length:	475	Species:	Mus musculus

Alignment Length:	276	Identity:	112/276 - (40%)
Similarity:	144/276 - (52%)	Gaps:	34/276 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 GHVKTISAARSECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENW 584
            |||.|:..  |.||..|...|  |||||..::..:||||||::      |...|.|||::|...|
Mouse   219 GHVVTLKC--SACGTRTGYSP--RIVGGNMSSLTQWPWQVSLQ------FQGYHLCGGSIITPLW 273

  Fly   585 IATAGHCVDDLLISQI-RIRVGEYDF------SHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLA 642
            |.||.|||.||...:. .::||....      ||:.|::.|          |.||.......|:|
Mouse   274 IVTAAHCVYDLYHPKSWTVQVGLVSLMDSPVPSHLVEKIIY----------HSKYKPKRLGNDIA 328

  Fly   643 LVKLEQPLEFAPHVSPICLPET-DSLLIGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKS 706
            |:||.:||.|...:.|||||.: ::...|.....:|||...:||....||...:||::||..|..
Mouse   329 LMKLSEPLTFDETIQPICLPNSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNH 393

  Fly   707 MFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFF-LAGIISWGIGCAEANLPG 770
            ..:..|   .|....|||||..||.|||||||||||..  |:.|.: |.|..|:||||||.|.||
Mouse   394 RDVYGG---IISPSMLCAGYLKGGVDSCQGDSGGPLVC--QERRLWKLVGATSFGIGCAEVNKPG 453

  Fly   771 VCTRISKFTPWILEHV 786
            |.|||:.|..||.|.:
Mouse   454 VYTRITSFLDWIHEQL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	100/247 (40%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	101/249 (41%)
Tmprss3	NP_001157248.1	LDLa	96..129	CDD:238060
		SRCR_2	134..233	CDD:292133	7/15 (47%)
		Tryp_SPc	238..465	CDD:214473	100/247 (40%)
		Tryp_SPc	239..468	CDD:238113	101/249 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8807
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740