DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sb and tmprss9

DIOPT Version :9

Sequence 1:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_002940084.3	Gene:	tmprss9 / 100489279	XenbaseID:	XB-GENE-993973	Length:	1151	Species:	Xenopus tropicalis

Alignment Length:	776	Identity:	198/776 - (25%)
Similarity:	270/776 - (34%)	Gaps:	273/776 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 PQTAFSYTRPTKPLTLRPRPPAAPYKPMISGMTTIERPHGAGTLVIRPSGPHHQGTLARPHPPPY 249
            |||:|:.|..|          ....:...:..||..||.           ..|..|.|:|.....
Frog   475 PQTSFTTTTTT----------TTGGRKTTNAKTTTARPF-----------TKHSTTRAKPASSTL 518

  Fly   250 QSKPTTASDLHGSASHPSSSSSSSSSSNPNSI------------WHTSTQQQQQQ---------- 292
            .||||...   .|...|....|....:.||.|            |..|.::..:.
Frog   519 PSKPTQKP---FSTIKPQECGSRPGLTKPNKIVGGLDAVRGEIPWQASLKEGSRHFCGATIIGDR 580

  Fly   293 -----QHQQNQQNHWQMTTE--------------------------------------------- 307
                 .|..||....|:|..
Frog   581 WLVSAAHCFNQTKVDQVTAHMGSTALSGADTIAIKISLKRVIQHPHFNPLTLDFDVAVLELASSL 645

  Fly   308 -----------PSFITKPRPTGW---------------TKP--------GIVNL----------- 327
                       ||.:.| .|.||               :||        ||::.
Frog   646 TFNKYVQPVCLPSALQK-FPAGWKCMISGWGNIKEGNVSKPEVLQKASVGIIDQKICSVLYNFSI 709

  Fly   328 -----------------------PMPARPSKPS--------------KPTKKPIVYDRTPPPP-- 353
                                   |:....| |.              ...|||.||.|.....
Frog   710 TERMICAGFLDGKVDSCQGDSGGPLACEES-PGIFFLAGIVSWGIGCAQAKKPGVYSRVTKLKDW 773

  Fly   354 --PSVPPSTSTSTTSTSLIWPAQTHPPQPHRPTRPQ-LSPGTSLAASSSSHWPSSTTSTTSSTTS 415
              .:|.|...|:.:..:|  |..:  |.|...|||. ..|.||..        ..||:.|..|.|
Frog   774 ILDTVAPVLRTTDSGMNL--PRSS--PLPISTTRPSTFQPATSNG--------RRTTTLTRPTMS 826

  Fly   416 TTTTTTTTRRTTTPTTTTRRTTTNKPTRPYQRPTTATSSSSTSTTSSKTPTTTRPISSSSSS--- 477
            .|.:|.:|.|:|| ..|::||||.|        |:.|:...|....|    |.||:..|:|:
Frog   827 QTKSTRSTPRSTT-KYTSKRTTTAK--------TSPTALRITEPARS----TQRPVPCSASTYKC 878

  Fly   478 SSGIVTSSQRPTQPTHRTPVLATSGI-ETNEISDSSIPDAGALGHVKTISAARSECG-VPTLARP 540
            |:.:..|...|          ...|| :.|..||..                ..:|| .|.|  |
Frog   879 SNRVCISKPNP----------ECDGIQDCNNGSDEQ----------------NCDCGFAPVL--P 915

  Fly   541 ETRIVGGKSAAFGRWPWQVS--VRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQIRIR 603
            ..:||||..:..|.||||||  :||       ..|:||..||::.|:.:|.||.|  :.|..::.
Frog   916 FNKIVGGSGSVRGEWPWQVSLWLRR-------KEHKCGAVLISDRWLLSAAHCFD--IYSDPKLW 971

  Fly   604 VGEYDFSHVQEQLPYIE--RGVAKKVV----HPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLP 662
            .....       .|::.  .|..:|:.    ||.|:..|.:.|:||::|..||.:...:.|||||
Frog   972 AAYLG-------TPFLNGVEGRVEKIFRIHKHPFYNVYTLDNDVALLELPSPLTYTNLIRPICLP 1029

  Fly   663 ETDSLL-IGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGY 726
            :...:. .|....:||||...|||.:...||:.||.||.:..||..:...     |....||||:
Frog  1030 DISHIFPEGTRCFITGWGSTKEGGAMSRQLQKASVSIVGDQTCKKFYPIQ-----ISPRMLCAGF 1089

  Fly   727 ETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHVR 787
            ..||.|||.||:||||..:...||:|||||.|||.|||....|||.|||:....||.:::|
Frog  1090 MQGGVDSCSGDAGGPLACREPSGRWFLAGITSWGYGCARPYFPGVYTRITSVRNWIGQNLR 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	93/247 (38%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	95/249 (38%)
tmprss9	XP_002940084.3	SEA	60..156	CDD:396113
		LDLa	186..221	CDD:238060
		Tryp_SPc	234..463	CDD:214473
		Tryp_SPc	547..774	CDD:238113	27/228 (12%)
		LDLa	871..906	CDD:238060	10/60 (17%)
		Tryp_SPc	919..1145	CDD:238113	93/246 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910