DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and RPS6KA5

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_004746.2	Gene:	RPS6KA5 / 9252	HGNCID:	10434	Length:	802	Species:	Homo sapiens

Alignment Length:	352	Identity:	161/352 - (45%)
Similarity:	217/352 - (61%)	Gaps:	24/352 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 TCNSSG-VKKVTLENFEFLKVLGKGTFGKVILCREKA---TAKLYAIKILKKEVIIQKDEVA-HT 311
            |.|.:| .:||.:||||.|||||.|.:|||.|.|:.:   |.||||:|:|||..|:||.:.. ||
Human    34 TANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHT 98

  Fly   312 LTESRVLKSTNH-PFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIIS 375
            .||.:||:.... |||::|.|:|||..:|..::.|:||||||.|||....|||...:.|..||:.
Human    99 RTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 163

  Fly   376 ALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTK--TFCGTPEYLAPEVLDD 438
            ||.:||..||||||:||||:|||.:||:.:.||||.||.:. ..|.:  :||||.||:||:::..
Human   164 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVA-DETERAYSFCGTIEYMAPDIVRG 227

  Fly   439 NDYG--QAVDWWGTGVVMYEMICGRLPF----YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAG 497
            .|.|  :|||||..||:|||::.|..||    .......:...||..|..:|:.::..||:|:..
Human   228 GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQR 292

  Fly   498 LLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESV 562
            ||.||||||||.|..|..||:.|.||..|||.||..||:|.||||.:..:.|...|.:|||
Human   293 LLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFT---- 353

  Fly   563 ELTPPDPTGPLGSI--AEEPLFPQFSY 587
            |:   |||....::  :.|.||..:|:
Human   354 EM---DPTYSPAALPQSSEKLFQGYSF 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	127/269 (47%)
		STKc_PKB	270..590	CDD:270723	151/333 (45%)
RPS6KA5	NP_004746.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		STKc_MSK1_N	48..337	CDD:270764	140/289 (48%)
		S_TK_X	320..379	CDD:214529	25/65 (38%)
		STKc_MSK1_C	418..727	CDD:271081
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940