Protein Alignment Akt and LATS1

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Alignment Length: 745
• Identity: 181/745 - (24%)
• Similarity: 302/745 - (40%)
• Gaps: 233/745 - (31%)

  Fly     5 PFVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINI-IY-------------SQSTHPNSSPTS 55
            |..||   |..::||:..:...||:|......|..|: :|             |.|....|||:|
Human   386 PSALQ---TGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSS 447

  Fly    56 GSAEKFSWQQSWPSRTSA--APTHDSGTMSINTTFDLSSPSVTSGHALT--------EQTQVVK- 109
            |. |..:||.:.|.|:::  .|..:..:.|.|     |.||.|:..|:|        :..:|:|
Human   448 GH-EIPTWQPNIPVRSNSFNNPLGNRASHSAN-----SQPSATTVTAITPAPIQQPVKSMRVLKP 506

  Fly   110 ----------EGWLMKRGEHIK----------------------NWR-----QRYFVLHSDGRLM 137
                      ..|:.:..:.::                      |::     ....:||.:..:.
Human   507 ELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVP 571

  Fly   138 GYR--SKPA--DSASTPSD-------------------FLLNNFTV---------RGCQIMTVDR 170
            .|.  |||:  |..|.|.:                   ...:..||         |..:|.:..
Human   572 PYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYS- 635

  Fly   171 PKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMA 235
            |:.|.|.               :|..:|     ..:::...||....::      :.:|..|.::
Human   636 PQAFKFF---------------MEQHVE-----NVLKSHQQRLHRKKQL------ENEMMRVGLS 674

  Fly   236 TIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKV--LGKGTFGKVILCREKATAKLYAIKILK 298
            ..|:|::.:....:.:  |...:|:..::...|:|:  ||.|.||:|.|.|:..|..|||.|.|:
Human   675 QDAQDQMRKMLCQKES--NYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLR 737

  Fly   299 KEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTE 363
            |:.::.:::|||...|..:|...::.:::.|.||||..|.|.|||.|:.||::...|....||.|
Human   738 KKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPE 802

  Fly   364 DRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLC----------------- 411
            ...|||.||:..|:..:|..|.|:||:|.:|:|:|:|||||:.|||||
Human   803 SLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDH 867

  Fly   412 -KEDI-----TYGRTTKTFC------------------------GTPEYLAPEVLDDNDYGQAVD 446
             ::|.     .:|..:...|                        |||.|:|||||....|.|..|
Human   868 PRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCD 932

  Fly   447 WWGTGVVMYEMICGRLPFY--------------------------------NRDHDVLFTLILVE 479
            ||..||:::||:.|:.||.                                .::.::....|::.
Human   933 WWSVGVILFEMLVGQPPFLAQTPLETQMKPGMVAHTCNPSALEGHSRKNTGTQEFEIGLGNIVIN 997

  Fly   480 ---EVKFP--RNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPP 539
               .:..|  ..::.||.:|:. .|.:.|:.||  ||:...||:|||||.:|:::. .|::....
Human   998 WQTSLHIPPQAKLSPEASDLII-KLCRGPEDRL--GKNGADEIKAHPFFKTIDFSS-DLRQQSAS 1058

  Fly   540 FKPQVTSDTDTRYFDKEFTGESVELTPPDP 569
            :.|::|..|||..||           |.||
Human  1059 YIPKITHPTDTSNFD-----------PVDP 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	23/178 (13%)
		STKc_PKB	270..590	CDD:270723	117/386 (30%)
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		PRK10263	<448..>596	CDD:236669	28/153 (18%)
		MobB_LATS1	629..704	CDD:439273	14/103 (14%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	118/390 (30%)