Protein Alignment Akt1 and SCH9

DIOPT Version :9

• Sequence 1: NP_732113.3
• Gene: Akt1 / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_012075.1
• Gene: SCH9 / 856612
• SGDID: S000001248
• Length: 824
• Species: Saccharomyces cerevisiae
• Alignment Length: 641
• Identity: 208/641 - (32%)
• Similarity: 314/641 - (48%)
• Gaps: 110/641 - (17%)

  Fly    16 ASAPAPGSASRIPESPTTTGSNIINII-------YSQSTHPNSSPTSGSAEKFSWQQSWPSRTSA 73
            |:|.|.|..:.||.     |...:.||       .|:.:.|....|..|:|..|   :.|....|
Yeast   169 AAAAAYGPDTDIPR-----GKLEVTIIEARDLVTRSKDSQPYVVCTFESSEFIS---NGPESLGA 225

  Fly    74 APTHDSG--------TMSINTTFDLSSPSVTSGHALTEQTQVVKEGW----LMKRGEHIKNWRQR 126
            ...:::.        ...||...:.::|...|.|...      ..||    |....||:|  ::.
Yeast   226 INNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNN------NSGWNGSQLPSIKEHLK--KKP 282

  Fly   127 YFVLHSDGRL--------------------MGYRSKPADSASTPSDFLLNNFTVRG----CQIMT 167
            .:...|..:|                    .|..:.|.:.:|.|.......|.|.|    ..|..
Yeast   283 LYTHRSSSQLDQLNSCSSVTDPSKRSSNSSSGSSNGPKNDSSHPIWHHKTTFDVLGSHSELDISV 347

  Fly   168 VDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDV 232
            .|......|:.:...:..:.....|     .:.||    .::..|:||
Yeast   348 YDAAHDHMFLGQVRLYPMIHNLAHA-----SQHQW----HSLKPRVID----------------- 386

  Fly   233 DMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKIL 297
               .:...::..:::.:.|.....|.     ::||.|::|||||||:|...::|.|.::||:|:|
Yeast   387 ---EVVSGDILIKWTYKQTKKRHYGP-----QDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVL 443

  Fly   298 KKEVIIQKDEVAHTLTESRVLKST---NHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHER 359
            .|:||::|:|:|||:.|..:|.:|   :.||::.||:||||...|..|..|::||||||||..|.
Yeast   444 SKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEG 508

  Fly   360 IFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTF 424
            .|:|||.:||.||::.||.:||...|:|||||.||:|||.:|:|.:.||||.|.|:.  ..|.||
Yeast   509 RFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLK--DRTNTF 571

  Fly   425 CGTPEYLAPE-VLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNI- 487
            |||.|||||| :||:..|.:.||:|..||:::||.||..||:..::..::..|...:|||||::
Yeast   572 CGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVL 636

  Fly   488 TDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRY 552
            :.|.::.:.|||.::||.|| |..||.:|::||||||.|:|..|..|||||||||.:.|:|||..
Yeast   637 SQEGRSFVKGLLNRNPKHRL-GAIDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSN 700

  Fly   553 FDKEFTGESVEL----TPPDPTGPLGSIAEEPLFPQFSYQGDMASTLGTSSHISTS 604
            ||.|||..|...    .|.....|| |.|.:..|..|::..:.|    ...|::.:
Yeast   701 FDPEFTTASTSYMNKHQPMMTATPL-SPAMQAKFAGFTFVDESA----IDEHVNNN 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	22/136 (16%)
		PH	107..211	CDD:278594	21/131 (16%)
		S_TKc	266..523	CDD:214567	126/261 (48%)
		STKc_PKB	270..590	CDD:270723	155/328 (47%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	42/270 (16%)
		STKc_Sck1_like	418..738	CDD:270738	155/323 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
TreeFam	0	0.000	Not matched by this tool.
	6	5.870