Protein Alignment Akt and PKC1

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 604
• Identity: 201/604 - (33%)
• Similarity: 305/604 - (50%)
• Gaps: 88/604 - (14%)

  Fly    19 PAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKF-SWQQSWPSRTSAAPTHDSGTM 82
            |:|....|  :|||.....||:...|..||...     ...|| ...:::.:.|..|
Yeast   600 PSPQKVGR--DSPTKQHDPIIDKRISLQTHGRE-----KLNKFIDENEAYLNFTEGA-------- 649

  Fly    83 SINTTFDLSSPSVTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSK----- 142
              ..|.:.|||..|.......::..:.:..:    ||.:.|..:..::..:..|...:.:
Yeast   650 --QQTAEFSSPEKTLDPTSNRRSLGLTDLSI----EHSQTWESKDDLMRDELELWKAQREEMELE 708

  Fly   143 -PADSASTPSDFLLNNFTVRGCQ-------------IMTVD--RPKPFTFIIRGLQWTTVIERTF 191
             ..||.....|..:::..:...|             .:|:|  ...||    |.:.     ..||
Yeast   709 IKQDSGEIQEDLEVDHIDLETKQKLDWENKNDFREADLTIDSTHTNPF----RDMN-----SETF 764

  Fly   192 AVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTC--- 253
            .:|.:       .|.:.|....:.:...:...|..|            |:.|.|.|...|:.
Yeast   765 QIEQD-------HASKEVLQETVSLAPTSTHASRTT------------DQQSPQKSQTSTSAKHK 810

  Fly   254 -NSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRV 317
             .::..:||:|:||..|||||||.||||||.:.|.|.:|.|||:|||:.|||..::.....|.:|
Yeast   811 KRAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKV 875

  Fly   318 L---KSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGY 379
            .   ..|.||||.:|..||||.:|:.|.|:::.||:|.||:.::|:... |.:||.||::.||.|
Yeast   876 FLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQRLSVR-RAKFYAAEVLLALKY 939

  Fly   380 LHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQA 444
            .|..|:|||||||||:||..:||||:||:||||:::.||..|.|||||||::|||:|.:.:|.:|
Yeast   940 FHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKA 1004

  Fly   445 VDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGG 509
            ||||..||::|:|:..:.||...|.|.:|..||.:|..:|.::..|...:..|||.|||:||||.
Yeast  1005 VDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGA 1069

  Fly   510 GKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLG 574
            |..|..|:...|||.:||:.|::..::.||:.|::.|..||.||::|||.     .||..| ||.
Yeast  1070 GPRDADEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTS-----APPTLT-PLP 1128

  Fly   575 SI---AEEPLFPQFSYQGD 590
            |:   :::..|..||:..|
Yeast  1129 SVLTTSQQEEFRGFSFMPD 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	18/129 (14%)
		STKc_PKB	270..590	CDD:270723	149/325 (46%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071
		C1_ScPKC1-like_rpt1	413..464	CDD:410372
		C1_ScPKC1-like_rpt2	478..536	CDD:410373
		STKc_PKC	828..1145	CDD:270722	149/323 (46%)