DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Prkci

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_114448.1	Gene:	Prkci / 84006	RGDID:	620961	Length:	596	Species:	Rattus norvegicus

Alignment Length:	368	Identity:	156/368 - (42%)
Similarity:	234/368 - (63%)	Gaps:	20/368 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 MTPSEQTDMTDVDMATI---------AEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGT 276
            |.|.:|:.|......|:         :.|::.|:.....|..:......:.|::|:.|:|:|:|:
  Rat   200 MMPMDQSSMHPDHTQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGS 264

  Fly   277 FGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVL-KSTNHPFLISLKYSFQTNDRLC 340
            :.||:|.|.|.|.::||:|::|||::...:::....||..|. :::|||||:.|...|||..||.
  Rat   265 YAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLF 329

  Fly   341 FVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKV 405
            ||::|||||:|.:|:..:|...|:..|||.|||..||.|||.:|||||||||:|:|||.:||||:
  Rat   330 FVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKL 394

  Fly   406 ADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF------ 464
            .|:|:|||.:..|.||.||||||.|:|||:|...|||.:||||..||:|:||:.||.||
  Rat   395 TDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459

  Fly   465 YNRD---HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLG-GGKDDVKEIQAHPFFAS 525
            .|.|   .|.||.:||.::::.||:::.:|.::|...|.||||:||| ..:....:||.||||.:
  Rat   460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRN 524

  Fly   526 INWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPD 568
            ::|..:..|::.|||||.::.:.....||.:||.|.|:|||.|
  Rat   525 VDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	128/267 (48%)
		STKc_PKB	270..590	CDD:270723	145/310 (47%)
Prkci	NP_114448.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Regulatory domain. /evidence=ECO:0000250	2..253		9/52 (17%)
		Required for interaction with RAB2. /evidence=ECO:0000250	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A. /evidence=ECO:0000250	72..91
		Pseudosubstrate. /evidence=ECO:0000250	125..134
		C1_aPKC	139..193	CDD:410344
		STKc_aPKC_iota	233..596	CDD:270769	149/335 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920