DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and PK1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001326081.1	Gene:	PK1 / 820020	AraportID:	AT3G08730	Length:	465	Species:	Arabidopsis thaliana

Alignment Length:	371	Identity:	145/371 - (39%)
Similarity:	227/371 - (61%)	Gaps:	21/371 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 DELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQ 304
            |:...:.:::|.....|||  |.:::||.:||:|||.||||...|:|.|:::||:|:::|:.|::
plant   110 DDSDNEKALEGDLVKVSGV--VGIDDFEVMKVVGKGAFGKVYQVRKKETSEIYAMKVMRKDHIME 172

  Fly   305 KDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFY 369
            |:...:...|..:|...:|||::.|||||||..||..|:.::|||.||:.|.|:.:|.||..|.|
plant   173 KNHAEYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVY 237

  Fly   370 GAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTK--TFCGTPEYLA 432
            .|||:||:.:||.:||::||||.||:|:|.|||:.:.||||.||   :...|:  :.|||.||:|
plant   238 TAEIVSAVSHLHEKGIMHRDLKPENILMDTDGHVMLTDFGLAKE---FEENTRSNSMCGTTEYMA 299

  Fly   433 PEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAG 497
            ||::....:.:|.|||..|:::|||:.|:.||......:. ..|:.:::|.|:.:::||..:|.|
plant   300 PEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSKGKIQ-QKIVKDKIKLPQFLSNEAHAILKG 363

  Fly   498 LLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESV 562
            ||.|:|::|||.|....:||:.|.:|..|||..|..:::.|.|||:|:.......|||.:|..||
plant   364 LLQKEPERRLGSGLSGAEEIKQHKWFKGINWKKLEAREVMPSFKPEVSGRQCIANFDKCWTDMSV 428

  Fly   563 ELTPPDPTGPLGSIAEEPL---FPQFSYQGDMASTLGTSSHISTST 605
                  ...|..|.:.:|.   |..|:|.....|.|    |.||:|
plant   429 ------LDSPASSPSSDPKANPFTNFTYVRPPPSFL----HQSTTT 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	111/258 (43%)
		STKc_PKB	270..590	CDD:270723	131/324 (40%)
PK1	NP_001326081.1	STKc_AGC	140..389	CDD:270693	107/252 (42%)
PK1	NP_001326081.1	S_TK_X	390..452	CDD:214529	21/67 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810