DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Prkch

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_112347.1	Gene:	Prkch / 81749	RGDID:	621888	Length:	683	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	176/343 - (51%)
Similarity:	231/343 - (67%)	Gaps:	12/343 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 GTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTE 314
            |...|||  .:..::||||::|||||:||||:|.|.|.|.:|||:|:|||:||:|.|:|..|:||
  Rat   341 GIGVNSS--SRFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTE 403

  Fly   315 SRVLK-STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALG 378
            .|:|. :.|||||..|...|||.|||.|||::||||:|.:|:...|.|.|.|.|||.|||||||.
  Rat   404 KRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468

  Fly   379 YLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQ 443
            :||.:|||||||||:|:|||.:||.|:||||:|||.|..|.||.||||||:|:|||:|.:..||.
  Rat   469 FLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGP 533

  Fly   444 AVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLG 508
            |||||..||::|||:||..||...:.|.||..||.:||.:|..:.::|..:|...:.|:|..|||
  Rat   534 AVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLG 598

  Fly   509 ----GGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDP 569
                ||:   .||..||||..|:|..|..:::.|||:|::.|..|...||.:|..|...|||.|
  Rat   599 SLTQGGE---HEILRHPFFKEIDWVQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPID- 659

  Fly   570 TGPLGSIAEEPLFPQFSY 587
            .|.|..|.::. |..|||
  Rat   660 EGHLPMINQDE-FRNFSY 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	145/261 (56%)
		STKc_PKB	270..590	CDD:270723	168/323 (52%)
Prkch	NP_112347.1	C2_PKC_epsilon	8..140	CDD:175981
		C1_1	172..225	CDD:278556
		C1_1	246..298	CDD:278556
		S_TKc	355..614	CDD:214567	145/261 (56%)
		STKc_nPKC_eta	359..681	CDD:270742	168/323 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910