DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and si:ch211-195b13.1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001070770.2	Gene:	si:ch211-195b13.1 / 768159	ZFINID:	ZDB-GENE-030131-7626	Length:	423	Species:	Danio rerio

Alignment Length:	379	Identity:	180/379 - (47%)
Similarity:	235/379 - (62%)	Gaps:	20/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 DVGEVAMTPSEQTDMTDVDM--ATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTF 277
            |||........|.:..|.::  .|.....|:|:..::.:             :|::||::|||:|
Zfish    51 DVGSFLKIDENQNEELDENLLCLTHPRSSLAEETQIKPS-------------DFDYLKIIGKGSF 102

  Fly   278 GKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVL-KSTNHPFLISLKYSFQTNDRLCF 341
            |||:|.|.|.....||:|:|:|::|::|.|..|.:.|..|| |:..||||:.|.|||||.|:|.|
Zfish   103 GKVLLARHKENELYYAVKVLQKKIIMKKKEQKHIMAERSVLMKNIKHPFLVGLHYSFQTTDKLYF 167

  Fly   342 VMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVA 406
            |:.||||||||:||..||:|.|.|.|||.|||.||||||||..|:|||||.||:|||..|||.:.
Zfish   168 VLDYVNGGELFYHLQRERVFLEPRARFYAAEIASALGYLHSLHIVYRDLKPENILLDSQGHIVLT 232

  Fly   407 DFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDV 471
            |||||||.:....||.||||||||||||||....|.:.||||..|.|::||:.|..|||:|:...
Zfish   233 DFGLCKEGLDPNGTTTTFCGTPEYLAPEVLQKQAYDRTVDWWCLGSVLFEMLYGLPPFYSRNTAE 297

  Fly   472 LFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKI 536
            ::..||.:.:....|:::..::||.|||.||..||| |.|||..|::.|.||:.|||.||:.|:|
Zfish   298 MYNNILHKPLVLKPNVSNAGRDLLEGLLHKDRTKRL-GSKDDFLELKFHSFFSPINWDDLMAKRI 361

  Fly   537 PPPFKPQVTSDTDTRYFDKEFT--GESVELTPPDPTGPLGSIAEEP-LFPQFSY 587
            .|||.|.||..||.|:||.|||  ..|..|...|......|:.|.. .||.|||
Zfish   362 VPPFIPTVTGPTDLRHFDPEFTHLPVSTSLCNTDNLHVTSSVREAAGAFPGFSY 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	139/257 (54%)
		STKc_PKB	270..590	CDD:270723	170/322 (53%)
si:ch211-195b13.1	NP_001070770.2	S_TKc	91..348	CDD:214567	139/257 (54%)
si:ch211-195b13.1	NP_001070770.2	STKc_SGK	95..415	CDD:270727	168/320 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820