DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and prkcd

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_002934267.1	Gene:	prkcd / 733756	XenbaseID:	XB-GENE-478663	Length:	683	Species:	Xenopus tropicalis

Alignment Length:	399	Identity:	174/399 - (43%)
Similarity:	238/399 - (59%)	Gaps:	29/399 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 EAIRNV----SSRLIDVG--EVAM-------TPS-EQTDMTDVDMATIAEDELSEQFSVQGTTCN 254
            ||:..|    |||..|.|  .:|:       ||. ...|.||...     |.|.|..|.......
Frog   288 EALNQVSMKSSSRKSDSGLDNIAIYQGVNPKTPGLPMPDATDNQY-----DRLWEGSSPHPHISL 347

  Fly   255 SSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK 319
            ||.:|   ::||.|.||||||:||||:|...|...:.:|||.|||:|::..|:|..|:.|.|||.
Frog   348 SSRLK---IDNFVFHKVLGKGSFGKVLLAELKGKGEYFAIKALKKDVVLIDDDVECTMVEKRVLA 409

  Fly   320 -STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQ 383
             :..:|||..:..||||.:.|.|||:::|||:|.:|:..:..|...|..||.:|||..|.:|||:
Frog   410 LAWENPFLTHIYCSFQTKEHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYASEIICGLQFLHSK 474

  Fly   384 GIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWW 448
            |||||||||:|::||||||||:||||:|||::.......||||||:|:|||:|....|..:||||
Frog   475 GIIYRDLKLDNVMLDKDGHIKIADFGMCKENVYGDNKASTFCGTPDYIAPEILQGLKYTFSVDWW 539

  Fly   449 GTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDD 513
            ..||::|||:.|:.||:..|.|.||..|..:...:||.||.|:|::|..|..::|.||||    .
Frog   540 SFGVLLYEMLIGQSPFHGDDEDELFESIRQDTPHYPRWITKESKDILERLFEREPTKRLG----V 600

  Fly   514 VKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAE 578
            |..|:.||||.:||||.|..:::.|||||:|.|.:|...||:||..|...|:..|..  |....:
Frog   601 VGNIKVHPFFKTINWTALERRELEPPFKPKVKSPSDYSNFDREFLSEKPRLSFSDKN--LIDSMD 663

  Fly   579 EPLFPQFSY 587
            :..|..||:
Frog   664 QSAFHGFSF 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	6/13 (46%)
		PH	107..211	CDD:278594	3/10 (30%)
		S_TKc	266..523	CDD:214567	126/257 (49%)
		STKc_PKB	270..590	CDD:270723	150/319 (47%)
prkcd	XP_002934267.1	C1_1	158..207	CDD:365894
		C1_1	230..280	CDD:365894
		STKc_nPKC_delta	360..675	CDD:173710	150/319 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910