Protein Alignment Akt1 and SGK1

DIOPT Version :9

• Sequence 1: NP_732113.3
• Gene: Akt1 / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001137148.1
• Gene: SGK1 / 6446
• HGNCID: 10810
• Length: 526
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 200/452 - (44%)
• Similarity: 262/452 - (57%)
• Gaps: 46/452 - (10%)

  Fly   159 TVRGCQIM-------TVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDV 216
            |..||::.       .:.:|.|.||      ||. .:..|..:..:....:.:.|.|.|
Human    90 TQSGCEVREPCNHANILTKPDPRTF------WTN-DDPAFMKQRRMGLNDFIQKIANNS------ 141

  Fly   217 GEVAMTPSEQTDMTDVDMATIAEDEL-----------SEQFSVQGTTCNSSGVKKVTLENFEFLK 270
             .....|..|:.:   .::...|.||           |:|.:: |.:.|.....    .:|.|||
Human   142 -YACKHPEVQSIL---KISQPQEPELMNANPSPPPSPSQQINL-GPSSNPHAKP----SDFHFLK 197

  Fly   271 VLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRV-LKSTNHPFLISLKYSFQ 334
            |:|||:||||:|.|.||....||:|:|:|:.|::|.|..|.::|..| ||:..||||:.|.:|||
Human   198 VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQ 262

  Fly   335 TNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDK 399
            |.|:|.||:.|:||||||:||..||.|.|.|.|||.|||.||||||||..|:|||||.||:|||.
Human   263 TADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDS 327

  Fly   400 DGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF 464
            .|||.:.|||||||:|.:..||.||||||||||||||....|.:.||||..|.|:|||:.|..||
Human   328 QGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF 392

  Fly   465 YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWT 529
            |:|:...::..||.:.::...|||:.|::||.|||.||..||| |.|||..||::|.||:.|||.
Human   393 YSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWD 456

  Fly   530 DLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELT---PPDPTGPLGSIAE-EPLFPQFSY 587
            ||:.|||.|||.|.|:...|.|:||.|||.|.|..:   .||......|:.| ...|..|||
Human   457 DLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	13/61 (21%)
		PH	107..211	CDD:278594	12/58 (21%)
		S_TKc	266..523	CDD:214567	146/257 (57%)
		STKc_PKB	270..590	CDD:270723	175/323 (54%)
SGK1	NP_001137148.1	S_TKc	193..450	CDD:214567	146/257 (57%)
		STKc_SGK	197..519	CDD:270727	175/323 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850