DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and RPS6KB2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_003943.2	Gene:	RPS6KB2 / 6199	HGNCID:	10437	Length:	482	Species:	Homo sapiens

Alignment Length:	399	Identity:	159/399 - (39%)
Similarity:	236/399 - (59%)	Gaps:	24/399 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 ELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKK 260
            :||.::.:|.          .||..::|::...:.::..|.:......|:..:..|:.| .|.::
Human     8 DLETEEGSEG----------EGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVN-VGPER 61

  Fly   261 VTLENFEFLKVLGKGTFGKVILCRE-KAT--AKLYAIKILKKEVIIQK-DEVAHTLTESRVLKST 321
            :....||.|:|||||.:|||...|: :.|  .|:||:|:|:|..|::. .:.|||..|..:|:|.
Human    62 IGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126

  Fly   322 NHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGII 386
            .|||::.|.|:|||..:|..:::.::|||||.||..|.||.||...||.|||..|||:|||||||
Human   127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGII 191

  Fly   387 YRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTG 451
            |||||.||::|...||||:.|||||||.|..|..|.|||||.||:|||:|..:.:.:|||||..|
Human   192 YRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLG 256

  Fly   452 VVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKE 516
            .:||:|:.|..||...:.......|:..::..|..:|.:|::|:...|.::|.:|:|||..|..:
Human   257 ALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAAD 321

  Fly   517 IQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTP---PDPTGPLGSIAE 578
            :|.||||..:||.||:..::.|||:|.:.|:.|...||..||.:    ||   ||.|. |...|.
Human   322 VQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQ----TPVDSPDDTA-LSESAN 381

  Fly   579 EPLFPQFSY 587
            : .|..|:|
Human   382 Q-AFLGFTY 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	3/17 (18%)
		PH	107..211	CDD:278594	3/14 (21%)
		S_TKc	266..523	CDD:214567	122/260 (47%)
		STKc_PKB	270..590	CDD:270723	145/325 (45%)
RPS6KB2	NP_003943.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		5/27 (19%)
		S_TKc	67..328	CDD:214567	122/260 (47%)
		STKc_p70S6K	70..392	CDD:270736	146/326 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..482
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12529391	471..477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840