DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and RPS6KA2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_006715612.1	Gene:	RPS6KA2 / 6196	HGNCID:	10431	Length:	761	Species:	Homo sapiens

Alignment Length:	342	Identity:	155/342 - (45%)
Similarity:	215/342 - (62%)	Gaps:	11/342 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 GVKKVTLENFEFLKVLGKGTFGKVILCRE---KATAKLYAIKILKKEVIIQKDEVAHTLTESRVL 318
            |.:|.....||.|||||:|::|||.|.|:   ....:|||:|:|||..:..:|.|...: |..:|
Human    78 GFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDIL 141

  Fly   319 KSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQ 383
            ...||||::.|.|:|||..:|..::.::.||:||..||.|.:|||:..:||.||:..||.:|||.
Human   142 AEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSL 206

  Fly   384 GIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWW 448
            ||||||||.||:|||::||||:.||||.||.|.:.:...:||||.||:||||::...:.|:.|||
Human   207 GIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWW 271

  Fly   449 GTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDD 513
            ..||:|:||:.|.|||..:|......|||..::..|:.::.||::||..|..::|..|||.|.|.
Human   272 SFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDG 336

  Fly   514 VKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAE 578
            |:||:.||||.:|:|..|..|:|.|||||.|....||.:||.|||..    ||.|..|...|...
Human   337 VEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTAR----TPTDSPGVPPSANA 397

  Fly   579 EPLFPQFSYQGDMASTL 595
            ..||..||:   :||:|
Human   398 HHLFRGFSF---VASSL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	121/259 (47%)
		STKc_PKB	270..590	CDD:270723	147/322 (46%)
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	121/259 (47%)
		STKc_RSK_N	91..407	CDD:270734	147/323 (46%)
		STKc_RSK3_C	439..731	CDD:271080
		Pkinase	443..700	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940