DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and RPS6KA1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001006666.1	Gene:	RPS6KA1 / 6195	HGNCID:	10430	Length:	744	Species:	Homo sapiens

Alignment Length:	335	Identity:	150/335 - (44%)
Similarity:	210/335 - (62%)	Gaps:	8/335 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 SGVKKVTLENFEFLKVLGKGTFGKVILCREKA---TAKLYAIKILKKEVIIQKDEVAHTLTESRV 317
            :|.:|....:||.|||||:|:||||.|.|:..   :..|||:|:|||..:..:|.| .|..|..:
Human    61 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDI 124

  Fly   318 LKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHS 382
            |...||||::.|.|:|||..:|..::.::.||:||..||.|.:|||:..:||.||:...|.:|||
Human   125 LADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189

  Fly   383 QGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDW 447
            .||||||||.||:|||::||||:.||||.||.|.:.:...:||||.||:||||::...:..:.||
Human   190 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADW 254

  Fly   448 WGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKD 512
            |..||:|:||:.|.|||..:|.....||||..::..|:.::.||::||..|..::|..|||.|.|
Human   255 WSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPD 319

  Fly   513 DVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIA 577
            ..:||:.|.|:::|:|..|..::|.|||||.|....||.|||.|||..    ||.|..|...|..
Human   320 GAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR----TPKDSPGIPPSAG 380

  Fly   578 EEPLFPQFSY 587
            ...||..||:
Human   381 AHQLFRGFSF 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	120/259 (46%)
		STKc_PKB	270..590	CDD:270723	145/321 (45%)
RPS6KA1	NP_001006666.1	S_TKc	71..329	CDD:214567	120/258 (47%)
		STKc_RSK_N	75..391	CDD:270734	145/321 (45%)
		STKc_RSK1_C	425..715	CDD:271077
		Pkinase	427..684	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940