DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and sgk1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_012818527.1	Gene:	sgk1 / 594981	XenbaseID:	XB-GENE-1003518	Length:	434	Species:	Xenopus tropicalis

Alignment Length:	336	Identity:	178/336 - (52%)
Similarity:	225/336 - (66%)	Gaps:	6/336 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 NFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRV-LKSTNHPFLIS 328
            :|:|||::|||:||||:|.|..|..|.||:|:|:|:.|::|.|..|.::|..| ||:..||||:.
Frog   100 DFQFLKIIGKGSFGKVLLARHNADEKFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 164

  Fly   329 LKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLE 393
            |.:||||..||.|::.|:||||||:||..||.|.|.|.|||.|||.||||||||..|:|||||.|
Frog   165 LHFSFQTTSRLYFILDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPE 229

  Fly   394 NLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMI 458
            |:|||..|||.:.|||||||:|....||.||||||||||||||....|.:.||||..|.|:|||:
Frog   230 NILLDSQGHIILTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 294

  Fly   459 CGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF 523
            .|..|||:|:...::..||.:.::...|||:.|:|||.|||.||..||: |.|:|..||:.|.||
Frog   295 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARNLLEGLLQKDRTKRI-GAKNDFMEIKNHMFF 358

  Fly   524 ASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELT---PPDPTGPLGSIAE-EPLFPQ 584
            :.|||.||:.|||.|||.|.|:..:|.::||.|||.|.|..:   .||......||.| ...|..
Frog   359 SPINWDDLINKKITPPFNPNVSGPSDLQHFDPEFTEEPVPNSIGQSPDSILITASIKEAAEAFMG 423

  Fly   585 FSYQGDMASTL 595
            |||...|.|.|
Frog   424 FSYAPPMESYL 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	143/257 (56%)
		STKc_PKB	270..590	CDD:270723	172/324 (53%)
sgk1	XP_012818527.1	STKc_SGK1	93..431	CDD:270753	175/331 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950