DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and rps6ka2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_699952.2	Gene:	rps6ka2 / 571285	ZFINID:	ZDB-GENE-090827-1	Length:	733	Species:	Danio rerio

Alignment Length:	366	Identity:	156/366 - (42%)
Similarity:	224/366 - (61%)	Gaps:	13/366 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 MATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCRE---KATAKLYAIK 295
            :..:.:|.:.::|.:....  ..|.:|.....||.|||||:|::|||.|.|:   ..|.:|||:|
Zfish    29 LCKLEDDSILKEFDISHHV--KEGFEKADPSQFELLKVLGQGSYGKVFLVRKIKGSDTGQLYAMK 91

  Fly   296 ILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERI 360
            :|||..:..:|.|...: |..:|...||||::.|.|:|||..:|..::.::.||:||..||.|.:
Zfish    92 VLKKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM 155

  Fly   361 FTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFC 425
            |||:..:||.||:..||.:|||.||||||||.||:|||::||||:.||||.||.|.:.:...:||
Zfish   156 FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFC 220

  Fly   426 GTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDE 490
            ||.||:||||::...:.|:.|||..||:|:||:.|.|||..:|......|||..::..|:.::.|
Zfish   221 GTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSPE 285

  Fly   491 AKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDK 555
            .::||..|..::|..|||.|.|.|:||:.|.|||:|:|..|..::|.|||||.|....||.:||.
Zfish   286 VQSLLRALFKRNPSNRLGAGPDGVEEIKRHIFFATIDWNKLYRREIKPPFKPAVGRPEDTFHFDP 350

  Fly   556 EFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGDMASTLG 596
            |||..    ||.|..|...|.....||..||:   :|:.||
Zfish   351 EFTSR----TPTDSPGVPASANAHQLFRGFSF---VATNLG 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	120/259 (46%)
		STKc_PKB	270..590	CDD:270723	146/322 (45%)
rps6ka2	XP_699952.2	S_TKc	59..318	CDD:214567	120/259 (46%)
		STKc_RSK_N	63..379	CDD:270734	146/323 (45%)
		PKc_like	411..703	CDD:304357
		Pkinase	415..672	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940