DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Rps6ka4

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_064308.2	Gene:	Rps6ka4 / 56613	MGIID:	1930076	Length:	773	Species:	Mus musculus

Alignment Length:	360	Identity:	158/360 - (43%)
Similarity:	217/360 - (60%)	Gaps:	23/360 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 MTDVDMATIAEDELSEQFSVQGTTCNSSG-VKKVTLENFEFLKVLGKGTFGKVILCREKA---TA 289
            |.|.|     ||| .....:|.|..|.:| .:||::|||..|||||.|.:|||.|.|:..   ..
Mouse     1 MGDED-----EDE-GCAVELQITEANLTGHEEKVSVENFALLKVLGTGAYGKVFLVRKTGGHDAG 59

  Fly   290 KLYAIKILKKEVIIQKDEV-AHTLTESRVLKSTNH-PFLISLKYSFQTNDRLCFVMQYVNGGELF 352
            ||||:|:|:|..::|:.:. .||.||..||:.... |||::|.|:|||:.:|..::.||:|||:|
Mouse    60 KLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124

  Fly   353 WHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITY 417
            .||...:.|.|...|.||.||:.||.:||..|||||||||||:|||.:|||.:.||||.||.:|.
Mouse   125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTE 189

  Fly   418 GR-TTKTFCGTPEYLAPEVLDDN-DYGQAVDWWGTGVVMYEMICGRLPF-----YNRDHDVLFTL 475
            .: .|.:||||.||:|||::... .:|:|||||..|::::|::.|..||     .|...:| ...
Mouse   190 EKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEV-SRR 253

  Fly   476 ILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPF 540
            ||.....||..|...|::||..||.||||||||.|....:|:::||||..::|..|..:|||.||
Mouse   254 ILKCSPPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPFFQGLDWVALAARKIPAPF 318

  Fly   541 KPQVTSDTDTRYFDKEFTGESVELTP---PDPTGP 572
            :||:.|:.|...|.:|||......:|   |.|..|
Mouse   319 RPQIRSELDVGNFAEEFTRLEPVYSPAGSPPPGDP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	123/268 (46%)
		STKc_PKB	270..590	CDD:270723	142/318 (45%)
Rps6ka4	NP_064308.2	STKc_MSK2_N	32..364	CDD:270765	145/323 (45%)
		S_TKc	33..301	CDD:214567	123/268 (46%)
		STKc_MSK2_C	404..714	CDD:271082
		S_TKc	417..674	CDD:214567
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940