DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and rps6ka5

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_693550.4	Gene:	rps6ka5 / 565173	ZFINID:	ZDB-GENE-130530-693	Length:	802	Species:	Danio rerio

Alignment Length:	368	Identity:	155/368 - (42%)
Similarity:	215/368 - (58%)	Gaps:	28/368 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 NSSG-VKKVTLENFEFLKVLGKGTFGKVILCREKA---TAKLYAIKILKKEVIIQKDEVA-HTLT 313
            |.:| |::|.:||||.|||||.|.:|||.|.|:.:   :.||||:|:|||..|:||.:.| ||.|
Zfish    25 NLTGHVERVGIENFELLKVLGTGAYGKVFLVRKVSGHDSGKLYAMKVLKKATIVQKAKTAEHTRT 89

  Fly   314 ESRVLKSTNH-PFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISAL 377
            |.:||:.... |||::|.|:|||:.:|..::.||||||||.||.....|.|.....|..||:.||
Zfish    90 ERQVLEHIRQSPFLVTLHYAFQTDTKLHLILDYVNGGELFTHLVQRVRFKEQEVTLYSGEIVLAL 154

  Fly   378 GYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYG 442
            .:||..||:||||||||:|||.:|||.:.||||.||.....| ..:.|||.||:|||::...:.|
Zfish   155 EHLHKLGIVYRDLKLENILLDSNGHIVLTDFGLSKEFHEVER-AYSICGTIEYMAPEIVAGGEGG 218

  Fly   443 --QAVDWWGTGVVMYEMICGRLPFY----NRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAK 501
              :|||||..||:|||::.|..||.    ...|..:...|:.::..||:::...||:::..||.|
Zfish   219 HDKAVDWWSMGVLMYELLTGGSPFTVDGDENSHSDIAERIMKKDPPFPKDMGPLAKDIIQRLLIK 283

  Fly   502 DPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTP 566
            |||||||.|....:.::.|||:..:||.||..||:..||||.:..:.|...|.:|||    |:.|
Zfish   284 DPKKRLGSGPSGAQNVKKHPFYQKLNWEDLAAKKVRAPFKPVIRDELDVSNFAEEFT----EMDP 344

  Fly   567 PDPTGPLGS-----------IAEEPLFPQFSYQGDMASTLGTS 598
            ......|.:           :|...||.:.:...|.|...|.|
Zfish   345 TYSPAALPNNCDRIFQGYSFMAPSILFKRNAVMDDPAQLCGGS 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	123/267 (46%)
		STKc_PKB	270..590	CDD:270723	142/341 (42%)
rps6ka5	XP_693550.4	PKc_like	37..367	CDD:304357	143/334 (43%)
		S_TKc	38..304	CDD:214567	122/266 (46%)
		PKc_like	405..714	CDD:304357
		S_TKc	419..663	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940