DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and rps6ka4

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_005165672.1	Gene:	rps6ka4 / 561959	ZFINID:	ZDB-GENE-060526-284	Length:	786	Species:	Danio rerio

Alignment Length:	354	Identity:	158/354 - (44%)
Similarity:	217/354 - (61%)	Gaps:	27/354 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 TTCNSSG-VKKVTLENFEFLKVLGKGTFGKVILCREKA---TAKLYAIKILKKEVIIQKDEVA-H 310
            |..|.:| .:||.:||||.|||||.|.:|||.|.|:.:   ..||||:|:|||..|:||.:.| |
Zfish    29 TNANLTGYTEKVGMENFELLKVLGTGAYGKVFLVRKISGHDKGKLYAMKVLKKAAIVQKAKTAEH 93

  Fly   311 TLTESRVLKSTNH-PFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEII 374
            |.||.:||:.... |||::|.|:|||..:|..::.||:|||:|.||.....|:||..|.|..|||
Zfish    94 TRTERQVLEHIRQSPFLVTLHYAFQTQTKLHLILDYVSGGEMFTHLYQRDHFSEDEVRIYVGEII 158

  Fly   375 SALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGR-TTKTFCGTPEYLAPEVL-D 437
            .||.:||..||:|||:||||:|||.|||:.:.||||.||.:...: .|.:||||.||:|||:: .
Zfish   159 LALEHLHKLGIVYRDIKLENILLDSDGHVVLTDFGLSKEFLEEEKERTYSFCGTIEYMAPEIIRG 223

  Fly   438 DNDYGQAVDWWGTGVVMYEMICGRLPF-----YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAG 497
            .:.:|:|||||..|::|:|::.|..||     .|...:| ...||..|..||..|...|::||..
Zfish   224 KSGHGKAVDWWSLGILMFELLTGASPFTLEGERNSQSEV-SKRILRCEPPFPSIIGPLAQDLLRK 287

  Fly   498 LLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTG--- 559
            |:.|||.||||.|....:||:.||||..:||:||..||:..||:|::..:.|...|.:||||
Zfish   288 LIVKDPHKRLGSGPRGAEEIKGHPFFKGLNWSDLAEKKVQSPFRPELRDELDVGNFAEEFTGMEP 352

  Fly   560 -ESVELTPPDPTGPLGSIAEEPLFPQFSY 587
             .|...|||         :.:.||..:|:
Zfish   353 VYSPASTPP---------STDRLFQGYSF 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	127/268 (47%)
		STKc_PKB	270..590	CDD:270723	148/334 (44%)
rps6ka4	XP_005165672.1	STKc_MSK2_N	44..375	CDD:270765	152/339 (45%)
		S_TKc	45..313	CDD:214567	127/268 (47%)
		STKc_MSK2_C	414..724	CDD:271082
		S_TKc	418..684	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940