DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and sgk2b

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_009290615.1	Gene:	sgk2b / 559050	ZFINID:	ZDB-GENE-060929-44	Length:	409	Species:	Danio rerio

Alignment Length:	379	Identity:	164/379 - (43%)
Similarity:	227/379 - (59%)	Gaps:	30/379 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 MTDVDMATIAEDELSEQFSVQGTTCNSSGVK-----KVTLENFEFLKVLGKGTFGKVILCREKAT 288
            ::|.|.||              ..|.|:.|:     :|:..:|::|||:|.|:||||.|...:..
Zfish    54 LSDDDRAT--------------AVCYSNPVREEPQSQVSAGDFDYLKVIGTGSFGKVFLATHREN 104

  Fly   289 AKLYAIKILKKEVIIQKDEVAHTLTESRV-LKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELF 352
            .|.||:|:|:|.:|:.:.|..:.:.|.|| ||:.|||||:.|.:||||.:||..|:.|..|||||
Zfish   105 GKYYAVKVLQKHIILTRKEERNVMCEHRVLLKTLNHPFLVKLHFSFQTKERLYLVLDYACGGELF 169

  Fly   353 WHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITY 417
            :||..|.:|.|.|.|||.||:..|||||||..|:|||||.||:|||..||:.:.|||||||.::.
Zfish   170 YHLQREGVFGEARARFYAAEMACALGYLHSLKIVYRDLKPENILLDSAGHVVLTDFGLCKEGMSG 234

  Fly   418 GRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVK 482
            ..||:||||||||||||||...:|.:.|||||.|.|::||:.|..||||.|...:...|:.:.:.
Zfish   235 RGTTRTFCGTPEYLAPEVLLQEEYDRTVDWWGLGAVLHEMLYGLPPFYNADRLEMLRNIIYQPLA 299

  Fly   483 FPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSD 547
            ....::..|::||..||.:|..||| |.|.|:.|:|:|.||:.|.|.:||.|||.||:.|.::..
Zfish   300 LKAGVSSAARDLLKRLLNRDRAKRL-GAKRDLIELQSHAFFSPIQWDELVAKKIQPPYVPVLSGP 363

  Fly   548 TDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPL-FPQFSYQGDMASTLGTSSH 600
            .|....|..||    ||..|.   .||:..:... ||.|::..:...:| |..|
Zfish   364 GDLTNIDPRFT----ELPVPH---SLGACEDHGANFPGFTFINENILSL-TRGH 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	129/257 (50%)
		STKc_PKB	270..590	CDD:270723	151/321 (47%)
sgk2b	XP_009290615.1	S_TKc	82..339	CDD:214567	129/257 (50%)
sgk2b	XP_009290615.1	PKc_like	86..398	CDD:304357	151/319 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920