Protein Alignment Akt and PRKACG

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 133/346 - (38%)
• Similarity: 201/346 - (58%)
• Gaps: 12/346 - (3%)

  Fly   220 AMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCR 284
            |...:||.:..:..:|....|.|....:....|.:|        :.||.|:.||.|:||:|:|.|
Human     6 AKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASS--------DQFERLRTLGMGSFGRVMLVR 62

  Fly   285 EKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGG 349
            .:.|...||:|||.|:.:::..:|.|.|.|.|:|::.:.|||:.|::||:.|..|..||:||.||
Human    63 HQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGG 127

  Fly   350 ELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKED 414
            |:|..|.....|:|....||.|:::.|:.||||..:|:||||.||||:|:.|:::|.|||..|.
Human   128 EMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKR- 191

  Fly   415 ITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVE 479
             ..|||. |.||||||||||::....|.:|||||..||::|||..|..|||......::..|:..
Human   192 -VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG 254

  Fly   480 EVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQV 544
            .|:||..::.:.|:||..||..|..||.|..::.|.:|:.|.:||:.:|..:..||:..||.|:.
Human   255 RVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKY 319

  Fly   545 TSDTDTRYFDKEFTGESVELT 565
            |...|...|| ::..|.:.::
Human   320 TGPGDASNFD-DYEEEELRIS 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947
		STKc_PKB	270..590	CDD:270723	122/296 (41%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	124/292 (42%)