DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and prkchb

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001038271.1	Gene:	prkchb / 556591	ZFINID:	ZDB-GENE-041001-104	Length:	676	Species:	Danio rerio

Alignment Length:	393	Identity:	180/393 - (45%)
Similarity:	253/393 - (64%)	Gaps:	30/393 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 VSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNS-SGVKKVTLENFEFLKVL 272
            ::|:|.::| :..|.|::.....:.|:::...  |...|::.|...| ....||.||:|.||:||
Zfish   292 LASKLSEIG-LLNTISKRKSQGSLHMSSVRSQ--SSTTSIETTEEESDEEAVKVCLEDFSFLQVL 353

  Fly   273 GKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSFQTN 336
            |||:||||:|.|.|:..:::|:|:|||:||:|:|:|..|:||.|||. :..||||..|.|.|||.
Zfish   354 GKGSFGKVMLARLKSDHRVFAVKMLKKDVILQEDDVEATMTEKRVLTLAHQHPFLTQLYYCFQTT 418

  Fly   337 DRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDG 401
            :||.|||::||||:|.:|:...|.|.|.|.:||.||:.|||.:|||:|||||||||:|:|||:||
Zfish   419 ERLFFVMEFVNGGDLMFHIQKCRRFDEPRAQFYAAEVTSALKFLHSKGIIYRDLKLDNILLDRDG 483

  Fly   402 HIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYN 466
            |.|:||||:|||:|..|:.|.||||||:|:|||:|.:..||.:||||..||::|||:.|..||..
Zfish   484 HCKLADFGMCKEEIFNGKLTSTFCGTPDYIAPEILQEELYGVSVDWWALGVLLYEMLSGHAPFEA 548

  Fly   467 RDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLG-----GGKDDVKEIQAHPFFASI 526
            ...|.||..||.:|:.:...::.||:::|.|||.:||..|||     ||::   .|.||.||..:
Zfish   549 ETEDELFECILKDEIIYSSWLSYEAEDILKGLLTRDPACRLGCIDNDGGEE---AITAHAFFTGL 610

  Fly   527 NWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFP-------Q 584
            :|..|..::|.|||.|::.|..|...||.:||.|...|||          .||.|||       .
Zfish   611 DWEKLYRREITPPFTPRINSIEDVNNFDPDFTQEDPCLTP----------IEESLFPFHQDGFKD 665

  Fly   585 FSY 587
            |||
Zfish   666 FSY 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	1/4 (25%)
		PH	107..211	CDD:278594	0/1 (0%)
		S_TKc	266..523	CDD:214567	139/262 (53%)
		STKc_PKB	270..590	CDD:270723	163/331 (49%)
prkchb	NP_001038271.1	C2_PKC_epsilon	3..133	CDD:175981
		C1_1	165..216	CDD:278556
		C1_1	236..288	CDD:278556
		S_TKc	347..607	CDD:214567	139/262 (53%)
		PKc_like	351..673	CDD:304357	163/331 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910